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Lowering Your Cholesterol May Decrease Your Risk Of Cancer

Date:
February 24, 2009
Source:
American Journal of Pathology
Summary:
Current research suggests that lowering cholesterol may block the growth of prostate tumors.
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Current research suggests that lowering cholesterol may block the growth of prostate tumors. 

High cholesterol not only leads to atherosclerosis and heart disease, but may also contribute to cancer growth and progression. Prostate cancer is the most common non-skin cancer in the United States, affecting approximately 1 in 6 men. Prostate tumors accumulate high levels of cholesterol, and tumor incidence correlates with eating a high fat/high cholesterol diet "Western" diet. In addition, prostate tumor progression has been linked to serum cholesterol levels.

To examine the role of high cholesterol in prostate cancer, Dr. Keith Solomon and colleagues fed mice a high fat/high cholesterol "Western" diet. They found that high cholesterol levels promoted tumor growth and that Ezetimibe (Zetia™), which blocks the absorption of cholesterol from the intestine, could prevent this increased tumor growth. Ezetimibe also blocked a cholesterol-mediated increase in angiogenesis, the growth of new blood vessels required for tumor progression. These data suggest that reducing cholesterol levels may inhibit prostate cancer growth specifically by inhibiting tumor angiogenesis.

The article from Solomon et al suggests "that cholesterol reduction, which is routinely accomplished pharmacologically in humans, may reduce angiogenesis, ultimately leading to less aggressive tumors." "Lowering cholesterol levels whether through diet, exercise, or the use of safe cholesterol-lowering drugs is known to provide a substantial benefit to patients—in the future it may be possible to add reduced risk of serious prostate cancer to that list of benefits" says Solomon. "We are in the process of working with clinicians to translate these findings into potential human studies. If we can demonstrate the effects noted in our pre-clinical studies in human patients we may be save lives and improve the quality of life," adds Dr. Michael Freeman, senior author of the study.

This work was supported by grants from the National Institutes of Health and the US Army Department of Defense.


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Solomon et al. Ezetimibe Is an Inhibitor of Tumor Angiogenesis. American Journal Of Pathology, 2009; 174 (3): 1017 DOI: 10.2353/ajpath.2009.080551

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American Journal of Pathology. "Lowering Your Cholesterol May Decrease Your Risk Of Cancer." ScienceDaily. ScienceDaily, 24 February 2009. <www.sciencedaily.com/releases/2009/02/090223121505.htm>.
American Journal of Pathology. (2009, February 24). Lowering Your Cholesterol May Decrease Your Risk Of Cancer. ScienceDaily. Retrieved May 30, 2015 from www.sciencedaily.com/releases/2009/02/090223121505.htm
American Journal of Pathology. "Lowering Your Cholesterol May Decrease Your Risk Of Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/02/090223121505.htm (accessed May 30, 2015).

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