Featured Research

from universities, journals, and other organizations

Getting Down To Specifics: Blocking One RANK Function Inhibits Bone Loss

Date:
March 2, 2009
Source:
Journal of Clinical Investigation
Summary:
A new report describes the development of a cell-permeable inhibitor that specifically blocks the contribution of the protein RANK to the formation and function of the cells responsible for breaking down bone. Importantly, this drug protected against bone loss in two mouse models of diseases associated with bone destruction, leading to the suggestion that this approach might be beneficial to individuals with diseases such as osteoporosis.

A new report describes the development of a cell-permeable inhibitor that specifically blocks the contribution of the protein RANK to the formation and function of the cells responsible for breaking down bone.

Importantly, this drug protected against bone loss in two mouse models of diseases associated with bone destruction, leading to the suggestion that this approach might be beneficial to individuals with diseases such as osteoporosis.

Soo Young Lee and colleagues, at Ewha Womans University, Republic of Korea, have developed a cell-permeable inhibitor of the mouse protein RANK (which they termed RRI) that is likely to aid in the development of selective drugs to treat diseases that involve substantial bone loss, for example, osteoporosis, periodontitis, and arthritis.

Central to understanding diseases that involve substantial loss of bone density, and thereby loss of bone strength, is insight into the molecules that regulate the formation and function of the cells that slowly breakdown bone, cells known as osteoclasts.

One molecule known to regulate both these processes is RANK, however, its utility as a target for drugs that prevent bone destruction might to be limited, as it is involved in many other biological functions.

The authors designed RRI to target a region of RANK that they recently found to be specific for the formation of osteoclasts. RRI was found to inhibit in vitro RANKL-induced formation of mouse osteoclasts and in vitro osteoclast-mediated bone destruction. More importantly, it protected against bone loss in two mouse models of diseases associated with bone destruction, leading to the suggestion similar drugs might be beneficial to individuals with diseases that involve bone destruction, such as osteoporosis.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kim et al. Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI36809

Cite This Page:

Journal of Clinical Investigation. "Getting Down To Specifics: Blocking One RANK Function Inhibits Bone Loss." ScienceDaily. ScienceDaily, 2 March 2009. <www.sciencedaily.com/releases/2009/03/090302183120.htm>.
Journal of Clinical Investigation. (2009, March 2). Getting Down To Specifics: Blocking One RANK Function Inhibits Bone Loss. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/03/090302183120.htm
Journal of Clinical Investigation. "Getting Down To Specifics: Blocking One RANK Function Inhibits Bone Loss." ScienceDaily. www.sciencedaily.com/releases/2009/03/090302183120.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins