Featured Research

from universities, journals, and other organizations

Skin Moles May Indicate Higher Eye Melanoma Risk

Date:
March 3, 2009
Source:
American Academy of Ophthalmology
Summary:
It is well known that people with light skin and numerous moles and freckles -- which develop when skin is over-exposed to UV light -- are at higher risk for skin cancer (cutaneous melanoma). But the evidence was less clear on whether moles and freckles also indicate a higher risk of uveal melanoma, cancer of the eye's iris, ciliary body, or choroid.

It is well known that people with light skin and numerous moles and freckles -- which develop when skin is over-exposed to UV light -- are at higher risk for skin cancer (cutaneous melanoma). But the evidence was less clear on whether moles and freckles also indicate a higher risk of uveal melanoma, cancer of the eye's iris, ciliary body, or choroid.

The iris is the colored area in the front of the eye, and the ciliary body and choroid supply blood flow and perform other vital functions deep within the eye.

Some earlier studies found a relationship between moles/freckles and higher uveal melanoma rates, but others did not.

A research team led by Ezekiel Weis, MD, MPH, Department of Ophthalmology, University of Alberta, Canada, performed a meta-analysis that adjusted for factors that might have skewed results of earlier studies.

His team's analysis showed associations between atypical moles (which appear different in shape or color from common moles), common moles, freckles, moles on the iris, and risk of uveal melanoma. For example, people with atypical moles are 2.8 times more likely to develop uveal melanoma than people with no such moles. This study suggests that doctors need to be extra vigilant when patients have numerous moles or freckles and that further research into the role of UV light in susceptible populations is required exposure.

Uveal cancer occurs in 6 persons per million annually and is the most common non-skin melanoma in the United States. It most often strikes people 70 or older who have light skin and eye color and a tendency to sunburn; these risk factors were identified by Dr. Weis and colleagues in earlier research. Caucasians are most susceptible, and risk levels decline as skin pigmentation increases across ethnic groups. Uveal melanoma may also result when melanoma from another site metastasizes.

In the early stages the disease usually has no symptoms. Although treatment is available, the mortality rate remains high, especially when the ciliary body or choroid is involved.

"We want to confirm risk factors that people will be able to modify, so we'll have a better chance of preventing uveal cancer, and we want to know which patients are most susceptible so we can begin treatment, when needed, as early as possible," said Dr. Weis. "Our study points to an interaction of genetic susceptibility and an environmental insult in the form of UV exposure."

The research is published in the March issue of Ophthalmology, the journal of the American Academy of Ophthalmology


Story Source:

The above story is based on materials provided by American Academy of Ophthalmology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Ophthalmology. "Skin Moles May Indicate Higher Eye Melanoma Risk." ScienceDaily. ScienceDaily, 3 March 2009. <www.sciencedaily.com/releases/2009/03/090302214529.htm>.
American Academy of Ophthalmology. (2009, March 3). Skin Moles May Indicate Higher Eye Melanoma Risk. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/03/090302214529.htm
American Academy of Ophthalmology. "Skin Moles May Indicate Higher Eye Melanoma Risk." ScienceDaily. www.sciencedaily.com/releases/2009/03/090302214529.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins