Featured Research

from universities, journals, and other organizations

Increased Dosage of Vancomycin May Lead to Hearing Loss in Older Patients

Date:
March 4, 2009
Source:
American Society for Microbiology
Summary:
A new study suggests that increasingly aggressive doses of vancomycin being prescribed to keep pace with the rising number of methicillin-resistant Staphylococcus aureus (MRSA) infections may cause high-frequency hearing loss in older patients.

A new study suggests that increasingly aggressive doses of vancomycin being prescribed to keep pace with the rising number of methicillin-resistant Staphylococcus aureus (MRSA) infections may cause high-frequency hearing loss in older patients.

The researchers from New York Medical College, Valhalla, New York, the University of the Pacific School of Pharmacy, Stockton, and Sharp Memorial Hospital, San Diego, CA report their findings in the February 2009 issue of the journal Antimicrobial Agents and Chemotherapy.

Although vancomycin has been available to medical professionals for 50 years, the emergence and rapid rise of MRSA in both community and healthcare settings has greatly increased its use. Additionally, recent increases in vancomycin minimum inhibiting concentrations (MICs) among MRSA isolates has resulted in many clinicians upping the dosage prescribed to patients.

In the study 89 patients taking vancomycin ranging in age from 16 to 86 were evaluated for high-frequency hearing loss detected by audiometry. They were administered a baseline audiogram (3 days after initiation of therapy) and then a follow-up test after an average of 27 days of therapy. Results showed a 12% rate of high-frequency hearing loss with a trend toward a higher rate with advanced age. Further analysis demonstrated a 0% rate of high-frequency hearing loss in patients under the age of 53 and a rate of 19% for patients over the age of 53.

"We conclude that a significant rate of high-frequency hearing loss in older patients receiving vancomycin monotherapy was detected by audiometry," say the researchers. "These findings should provide an additional caution against the use of indiscriminately higher doses of vancomycin to chase increasing vancomycin MICs for MRSA strains causing serious infections, such as pneumonia or bacteremia, in older patients."


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Forouzesh, P.A. Moise, G. Sakoulas. Vancomycin ototoxicity: a reevalutaion in an era of increasing doses. Antimicrobial Agents and Chemotherapy, 53. 2: 483-486

Cite This Page:

American Society for Microbiology. "Increased Dosage of Vancomycin May Lead to Hearing Loss in Older Patients." ScienceDaily. ScienceDaily, 4 March 2009. <www.sciencedaily.com/releases/2009/03/090304091339.htm>.
American Society for Microbiology. (2009, March 4). Increased Dosage of Vancomycin May Lead to Hearing Loss in Older Patients. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2009/03/090304091339.htm
American Society for Microbiology. "Increased Dosage of Vancomycin May Lead to Hearing Loss in Older Patients." ScienceDaily. www.sciencedaily.com/releases/2009/03/090304091339.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com
Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Newsy (Apr. 14, 2014) Richard van As lost all fingers on his right hand in a woodworking accident. Now, he's used the incident to create a prosthetic to help hundreds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins