Featured Research

from universities, journals, and other organizations

Patients Who Wake Up With Stroke May Be Candidates For Clot-busters

Date:
March 12, 2009
Source:
University of Texas Health Science Center at Houston
Summary:
Giving clot-busting drugs to patients who wake up with stroke symptoms appears to be as safe as giving it to those in the recommended three-hour window, according to researchers.

Giving clot-busting drugs to patients who wake up with stroke symptoms appears to be as safe as giving it to those in the recommended three-hour window, according to researchers at The University of Texas Medical School at Houston.

"The results of our study serve as the only published material of patients who woke up with ischemic stroke symptoms and were treated with thrombolytic therapy," said Andrew Barreto, M.D., lead author and assistant professor of neurology at the UT Medical School at Houston. "It stands as the only support for the safety of stroke treatment in wake-up stroke patients."

Stroke occurs when blood flow to the brain is interrupted by a blockage or a rupture in an artery, depriving brain tissue of oxygen. It is the third-leading cause of death behind heart disease and cancer. According to the American Stroke Association, nearly 800,000 Americans suffer a stroke each year – one every 40 seconds. On average, someone dies of stroke every three to four minutes.

According to protocol from the U.S. Food and Drug Administration, thrombolytic medications such as intravenous tissue plasminogen activator (tPA) should be given to patients with a blockage within three hours of the onset of stroke symptoms.

Approximately 25 percent of patients with a blockage, called an ischemic stroke, wake up with their symptoms. That could place them outside the three-hour window and therefore they are not normally given tPA, except under an off-label, compassionate care exemption.

"The offer of compassionate tPA treatment was made by the treating stroke neurologist," Barreto said. "Usually these were younger patients with moderate to severe disabling strokes who had no other treatment options."

The researchers compared 174 patients who were treated with tPA within the three-hour, standard-of-care window with 46 wake-up stroke patients who received off-label thrombolytic therapy. The two groups experienced similar rates of excellent outcomes and favorable outcomes.

In addition, wake-up stroke patients treated with thrombolytic therapy have higher rates of excellent and favorable outcomes than wake-up stroke patients who did not receive it, according to the research.

Barreto said further studies will need to occur to verify the results.

"An indication for treatment of thrombolytic therapy will only come after large, randomized, blinded/controlled clinical trials are conducted," he said. Barreto and senior author Sean Savitz, M.D., assistant professor of neurology at the medical school, are currently working with other stroke centers to create collaboration and set up such a trial.

Other study researchers from medical school's Department of Neurology are Hen Hallevi, M.D., research collaborator; Anitha Abraham, M.D. clinical research fellow; Nicole Gonzales, M.D. assistant professor; and James Grotta, M.D. professor and chair.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at Houston. Note: Materials may be edited for content and length.


Journal Reference:

  1. Barreto et al. Thrombolytic Therapy for Patients Who Wake-Up With Stroke. Stroke, 2009; 40 (3): 827 DOI: 10.1161/STROKEAHA.108.528034

Cite This Page:

University of Texas Health Science Center at Houston. "Patients Who Wake Up With Stroke May Be Candidates For Clot-busters." ScienceDaily. ScienceDaily, 12 March 2009. <www.sciencedaily.com/releases/2009/03/090312165206.htm>.
University of Texas Health Science Center at Houston. (2009, March 12). Patients Who Wake Up With Stroke May Be Candidates For Clot-busters. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/03/090312165206.htm
University of Texas Health Science Center at Houston. "Patients Who Wake Up With Stroke May Be Candidates For Clot-busters." ScienceDaily. www.sciencedaily.com/releases/2009/03/090312165206.htm (accessed July 31, 2014).

Share This




More Mind & Brain News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins