Featured Research

from universities, journals, and other organizations

Combination Therapy Restores T Cell Numbers In HIV-infected Individuals

Date:
March 22, 2009
Source:
Journal of Clinical Investigation
Summary:
CD4+ T cell depletion by HIV is a major blow to the immune system. Combination antiretroviral therapy (c-ART) restores the T cell population, however not all patients respond to this therapy. Researchers report that administration of interleukin-7 (IL-7) to c-ART--treated, HIV-infected patients with low T cell counts, boosted T cell numbers and was well tolerated for 48 weeks. HIV-infected patients may benefit from intermittent IL-7 therapy in combination with c-ART.

CD4+ T cell depletion by HIV is a major blow to the immune system. Combination antiretroviral therapy (c-ART) restores the T cell population, however not all patients respond to this therapy.

Related Articles


University of Paris researchers report that administration of interleukin-7 (IL-7) to c-ART--treated, HIV-infected patients with low T cell counts, boosted T cell numbers and was well tolerated for 48 weeks. HIV-infected patients may benefit from intermittent IL-7 therapy in combination with c-ART.

White blood cells known as CD4+ T cells are the main target of HIV. The virus hijacks these cells and replicates within them, which ultimately destroys the cell. This depletion of the T cell population represents a major blow to the immune system and puts HIV-infected individuals at increased risk of opportunistic infections. Treatment of HIV-infected individuals with a cocktail of drugs called combination antiretroviral therapy (c-ART) is able to restore the T cell population and help fight HIV infection, however not all patients respond to this therapy. The growth factor interleukin-7 (IL-7) is known to stimulate T cell production and survival, suggesting that IL-7 may help restore the T cell population during HIV infection.

In a new study published in the JCI, Yves Levy and colleagues at the University of Paris undertook a clinical trial to evaluate the safety and efficacy of repeated IL-7 therapy over a 16-day period in 13 c-ART–treated, HIV-infected patients that possessed low T cell counts despite successful suppression of virus levels with c-ART. In these individuals, IL-7 was well tolerated and boosted the number of CD4+ and CD8+ T cells, which were able to mount an immune response against HIV. These effects were observed for 48 weeks. The data suggest that HIV-infected patients may benefit from intermittent therapy with IL-7 in combination with c-ART.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Levy et al. Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI38052

Cite This Page:

Journal of Clinical Investigation. "Combination Therapy Restores T Cell Numbers In HIV-infected Individuals." ScienceDaily. ScienceDaily, 22 March 2009. <www.sciencedaily.com/releases/2009/03/090316173313.htm>.
Journal of Clinical Investigation. (2009, March 22). Combination Therapy Restores T Cell Numbers In HIV-infected Individuals. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/03/090316173313.htm
Journal of Clinical Investigation. "Combination Therapy Restores T Cell Numbers In HIV-infected Individuals." ScienceDaily. www.sciencedaily.com/releases/2009/03/090316173313.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins