Featured Research

from universities, journals, and other organizations

Proteinuria During Pre-eclampsia: A Poor Predictor Of Complications?

Date:
March 23, 2009
Source:
BioMed Central
Summary:
The estimation of levels of proteinuria in women with pre-eclampsia is not a clinically useful test to predict fetal or maternal outcomes. Researchers present evidence that could change current clinical practice.

The estimation of levels of proteinuria in women with pre-eclampsia is not a clinically useful test to predict fetal or maternal outcomes. Researchers publishing in the open access journal BMC Medicine, present evidence that could change current clinical practice.

Related Articles


Proteinuria, its presence and degree, is currently an essential criterion in diagnosing pre-eclampsia and is widely considered to predict adverse outcomes for mother and fetus. In a systematic, quantitative review of 16 primary research articles including 6749 women, the authors found that proteinuria was a poor predictor of maternal and fetal complications. Outcomes tested for included eclampsia, abruption, HELLP syndrome, stillbirth, neonatal death, perinatal death, small for gestational age and NICU admission.

Shakila Thangaratinam of Birmingham Women's Hospital and her colleagues used four databases (MEDLINE, EMBASE, MEDION and the Cochrane Library) to select the studies for systematic review. By calculating likelihood ratios for positive and negative test results for each individual test threshold and each outcome of interest, they demonstrated the clinical relevance of assessing proteinuria levels in pre-eclampsia for each outcome. The LRs were not significant for any adverse maternal outcome. At cut-off level of proteinuria of 5g in 24hours, they found a slight association with stillbirths for positive test results. However, with no significant positive and negative LRs, proteinuria estimates were found to be poor predictors of neonatal and perinatal deaths.

According to Thangaratinam, 'Our systematic review has shown proteinuria levels in pre eclampsia to be poor predictors of adverse maternal and fetal outcomes. We need large well-conducted studies to estimate the risk of complications especially in the subgroup of women who have pre eclampsia before 34 weeks when the management decision is often critical to mother and baby.'


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shakila Thangaratinam, Arri Coomarasamy, Fidelma O'Mahony, Steve Sharp, Javier Zamora, Khalid S Khan and Khaled MK Ismail. Estimation of proteinuria as a predictor of complications of pre-eclampsia: a systematic review. BMC Medicine, 2009; (in press) [link]

Cite This Page:

BioMed Central. "Proteinuria During Pre-eclampsia: A Poor Predictor Of Complications?." ScienceDaily. ScienceDaily, 23 March 2009. <www.sciencedaily.com/releases/2009/03/090323211923.htm>.
BioMed Central. (2009, March 23). Proteinuria During Pre-eclampsia: A Poor Predictor Of Complications?. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2009/03/090323211923.htm
BioMed Central. "Proteinuria During Pre-eclampsia: A Poor Predictor Of Complications?." ScienceDaily. www.sciencedaily.com/releases/2009/03/090323211923.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins