Featured Research

from universities, journals, and other organizations

Intensively Lowering Blood Glucose In Critically Ill Patients Increases The Risk Of Death, Trial Finds

Date:
March 25, 2009
Source:
The George Institute for International Health
Summary:
The current practice of intensively lowering blood glucose in critically ill patients increases the risk of death by 10 percent. Results of the largest trial of intensive glucose lowering in critically ill patients indicate that international clinical guidelines need urgent review.

The current practice of intensively lowering blood glucose in critically ill patients increases the risk of death by 10%. Results of the largest trial of intensive glucose lowering in critically ill patients published in The New England Journal of Medicine indicate that international clinical guidelines need urgent review.

Intensive blood glucose lowering has been widely recommended and embraced to control hyperglycemia (high blood sugar) which is extremely common among acutely ill patients and linked with serious complications such as organ failure and death. These new findings reveal that current practice to intensively lower blood glucose increases the risk of death among patients in the intensive care unit (ICU).

"Intensively lowering blood glucose in critically ill patients is not beneficial and may be harmful. Based on our findings, we do not recommend pursuing a normal blood glucose level in critically ill patients. We found that intensively lowering blood glucose levels increased a patient's risk of dying by 10%," said Chief Investigator, Professor Simon Finfer from The George Institute for International Health, which is affiliated with the University of Sydney.

Researchers from The Australian and New Zealand Intensive Care Society Clinical Trials Group, The George Institute for International Health, The Canadian Critical Care Trials Group and Vancouver Coastal Health Research Institute set out to clarify the target range for blood glucose levels in critically ill patients. They followed 6104 ICU patients in Australia, New Zealand, Canada and the USA for up to 90 days to assess whether the treatment would improve patients' chance of survival.

"Previous, smaller research studies have produced conflicting results and overall suggested that intensive blood glucose control didn't affect death rates in critically ill adults. This new study gives us more powerful information, based on this larger study with stronger evidence, we can conclude that targeting very low levels of blood glucose is not safe," said North American Chief Investigator Dr Dean Chittock of Vancouver Coastal Health and University of British Columbia, Vancouver, Canada.

There are over six million admissions each year to ICU's in North America. The new evidence suggests that current guidelines must be reviewed.

"It's essential that international guidelines reflect this new evidence. Many professional organizations recommend very tight glucose control for ICU patients – they will now need to take this new evidence into consideration and adjust recommendations accordingly," added Dr Chittock.

The study, NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) randomly assigned patients to one of two target ranges for blood glucose; an intensive control target (81-108mg/dL; 4.5-6.0 mmol/L) or a conventional control target (180mg/dL; 10.0 mmol/L or less). Control of blood glucose was achieved by the use of an intravenous infusion of insulin.

A unique feature of the NICE-SUGAR study was standardized complex blood glucose management, which was accessed by multiple centres as a computerized algorithm.


Story Source:

The above story is based on materials provided by The George Institute for International Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. The NICE-SUGAR Study Investigators. Intensive versus Conventional Glucose Control in Critically Ill Patients. N Engl J Med, 2009; DOI: 10.1056/NEJMoa0810625

Cite This Page:

The George Institute for International Health. "Intensively Lowering Blood Glucose In Critically Ill Patients Increases The Risk Of Death, Trial Finds." ScienceDaily. ScienceDaily, 25 March 2009. <www.sciencedaily.com/releases/2009/03/090324101604.htm>.
The George Institute for International Health. (2009, March 25). Intensively Lowering Blood Glucose In Critically Ill Patients Increases The Risk Of Death, Trial Finds. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2009/03/090324101604.htm
The George Institute for International Health. "Intensively Lowering Blood Glucose In Critically Ill Patients Increases The Risk Of Death, Trial Finds." ScienceDaily. www.sciencedaily.com/releases/2009/03/090324101604.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins