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Protective Role For Kallikrein Proteins In Kidney Disease

Date:
April 3, 2009
Source:
Journal of Clinical Investigation
Summary:
A team of researchers has shed new light on several forms of the kidney disease known as nephritis.

A team of researchers, at the University of Texas Southwestern Medical Center, Dallas, and Uppsala University, Sweden, has shed new light on several forms of the kidney disease known as nephritis.

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Specifically, the data indicate a protective role for kallikrein proteins in anti-GBM antibody–induced nephritis (a mouse model of Goodpasture syndrome) and spontaneous lupus nephritis in mice and humans.

In the study, which was led by Chandra Mohan, Edward Wakeland, and Marta Alarcσn-Riquelme, kallikrein genes were found to be underexpressed in the kidneys of mouse strains sensitive to anti-GBM antibody–induced nephritis.

Conversely, mouse strains that upregulated kallikreins in the kidneys showed fewer signs of disease. Consistent with this, antagonizing the kallikrein pathway enhanced disease and agonists dampened disease severity.

As both human systemic lupus erythematosus and spontaneous lupus nephritis were found to be associated with kallikrein genes, the authors conclude that kallikreins are protective disease-associated genes in anti-GBM antibody–induced nephritis and lupus.

In an accompanying commentary, Claudio Ponticelli and Pier Luigi Meroni, at IRCCS Istituto Clinico Humanitas, Italy, discuss this possibility and suggest alternative roles for kallikreins in lupus nephritis.

The research is published in the March 23, 2009, issue of the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Liu et al. Kallikrein genes are associated with lupus and glomerular basement membrane%u2013specific antibody%u2013induced nephritis in mice and humans. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI36728
  2. Claudio Ponticelli, Pier Luigi Meroni. Kallikreins and lupus nephritis. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI38786

Cite This Page:

Journal of Clinical Investigation. "Protective Role For Kallikrein Proteins In Kidney Disease." ScienceDaily. ScienceDaily, 3 April 2009. <www.sciencedaily.com/releases/2009/03/090324213438.htm>.
Journal of Clinical Investigation. (2009, April 3). Protective Role For Kallikrein Proteins In Kidney Disease. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2009/03/090324213438.htm
Journal of Clinical Investigation. "Protective Role For Kallikrein Proteins In Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2009/03/090324213438.htm (accessed January 25, 2015).

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