Featured Research

from universities, journals, and other organizations

Protein From Tick Saliva Studied For Potential Myasthenia Gravis Treatment

Date:
April 4, 2009
Source:
Saint Louis University
Summary:
Researchers have found that a protein in tick saliva shows promise as a potential treatment for the debilitating neuromuscular disorder myasthenia gravis.

Looking for a better treatment for the autoimmune disease myasthenia gravis, researchers have found that a protein in tick saliva shows promise in limiting the severity of the disease in an animal model in a study published in the Annals of Neurology.

Related Articles


"This disease can leave patients weak and on breathing machines, and conventional treatments can be toxic," said Henry Kaminski, M.D., chair of the department of neurology and psychiatry at Saint Louis University and one of the nation's leading experts on myasthenia gravis. "There is a real need for better treatments. This study is a step in that direction."

Myasthenia gravis is a highly debilitating, chronic neuromuscular disorder that affects about 400 to 600 per 1 million people, and roughly 1,100 to 1,700 people in the St. Louis area. Symptoms include weakness in the arms and legs, chronic muscle fatigue, difficulty breathing, difficulty chewing and swallowing, slurred speech, droopy eyelids and blurred or double vision.

While drugs like prednisone, a corticosteroid, can be effective in treating the disorder, they also can carry a host of severe side effects, including pronounced weight gain, osteoporosis, glaucoma and diabetes.

Other treatments, intravenous immunoglobulin and plasmapheresis, which involve blood plasma, are expensive and can have rare but serious side-effects such as infections, heart attacks and stroke.

Doctors believe that myasthenia gravis is caused by an overreaction of the complement system, a component of the immune system that specifically defends against parasites, bacteria and other pathogens. Antibodies block nerve receptors at the neuromuscular junction, the place where nerves connect with muscles, and then activate complement which prevents muscle contraction from occurring, causing weakness.

To impede the complement system's misplaced response, researchers hope a new class of drugs, called complement inhibitors, may stop the body's defense system from attacking itself.

Other researchers discovered that rEV576, a protein found in tick saliva, works as a complement inhibitor, allowing ticks to avoiding setting off an immune response in their human host.

SLU researchers in collaboration with Varleigh Limited tested the protein on two groups of rats with mild and severe models of myasthenia gravis. The health of rats that were given the complement inhibitor rEV576 improved, with reduced weakness and weight loss.

Researchers hope rEV576 could have therapeutic value in human myasthenia gravis. And, because ticks apply themselves to people without causing a reaction, researchers are optimistic that rEV576 will not cause allergic reactions or other negative side effects.

"Complement inhibitors are a completely new class of drugs," said Kaminski. "This one will probably prove to be superior to what we've seen. Since complement is activated in many diseases such as Alzheimer's, stroke and rheumatoid arthritis, our studies may be important for other diseases."


Story Source:

The above story is based on materials provided by Saint Louis University. Note: Materials may be edited for content and length.


Cite This Page:

Saint Louis University. "Protein From Tick Saliva Studied For Potential Myasthenia Gravis Treatment." ScienceDaily. ScienceDaily, 4 April 2009. <www.sciencedaily.com/releases/2009/03/090326084754.htm>.
Saint Louis University. (2009, April 4). Protein From Tick Saliva Studied For Potential Myasthenia Gravis Treatment. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2009/03/090326084754.htm
Saint Louis University. "Protein From Tick Saliva Studied For Potential Myasthenia Gravis Treatment." ScienceDaily. www.sciencedaily.com/releases/2009/03/090326084754.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins