Featured Research

from universities, journals, and other organizations

Enzyme And Vitamin Define The Yin And Yang Of Asthma

Date:
April 6, 2009
Source:
Baylor College of Medicine
Summary:
The allergen breathed in by a person with asthma triggers a proteinase or enzyme called MMP7 that activates a cascade of events to prompt an allergic reaction. In particular, MMP7 activates interleukin 25, a key mediator of the allergic response in the lung. Researchers have identified a form of vitamin A made in the lung that is critical for dampening the inflammatory effect.

The allergen breathed in by a person with asthma triggers a proteinase or enzyme called MMP7 that activates a cascade of events to prompt an allergic reaction, said a consortium of researchers led by Baylor College of Medicine in Houston in a report that appears online March 29 in the journal Nature Immunology.

Related Articles


In particular, MMP7 activates interleukin 25, a key mediator of the allergic response in the lung said Drs. Farrah Kheradmand  and David B. Corry, associate professors of medicine-pulmonary at BCM, and senior authors of the report.

In the same report, the researchers report that they have identified a form of vitamin A made in the lung that is critical for dampening the inflammatory effect. Mice that lack MMP7 were found to have higher production of retinal dehydrogenase, an enzyme that is responsible for synthesizing vitamin A in the lung. MMP7 deficient mice showed less lung inflammation when they are exposed to allergens than did mice who had enough MMP7. Suppressing the production of vitamin A restored the asthmatic symptoms in the MMP7 deficient mice.

"It is important to know which mediators in the airway may be setting off the initial cascade of events that result in the asthmatic reaction in the lung; it would be like getting to the top of the food chain," they said.

In the future, they said, they hope to identify the relationship between the synthesis of vitamin A in the body and the repression of MMP7.

Others who took part in this work include Sangeeta Goswami, Ming Shan, Wade T. Barranco, Sumanth Polikepahad, Alexander Seryshev and Li-Zhen Song, all of BCM; Pornpimon Angkasekwinai and Chen Dong of The University of Texas M.D. Anderson Cancer Center in Houston; Kendra J. Greenlee of North Dakota State University in Fargo; David Redding, Bhupinder Singh and Sanjiv Sur of U.T. Medical Branch in Galveston, and Prescott Woodruff of the University of California, San Francisco.

Funding for this comes from the National Institutes of Health, the American Lung Association, the Leukemia and Lymphoma Society and The UT MD Anderson Cancer Center.


Story Source:

The above story is based on materials provided by Baylor College of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College of Medicine. "Enzyme And Vitamin Define The Yin And Yang Of Asthma." ScienceDaily. ScienceDaily, 6 April 2009. <www.sciencedaily.com/releases/2009/03/090329143328.htm>.
Baylor College of Medicine. (2009, April 6). Enzyme And Vitamin Define The Yin And Yang Of Asthma. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/03/090329143328.htm
Baylor College of Medicine. "Enzyme And Vitamin Define The Yin And Yang Of Asthma." ScienceDaily. www.sciencedaily.com/releases/2009/03/090329143328.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins