Featured Research

from universities, journals, and other organizations

Lithium Protects Brain Cells During Cranial Radiation

Date:
April 1, 2009
Source:
Journal of Clinical Investigation
Summary:
Cranial radiation therapy to treat brain cancer can result in various long-term neurological side effects, particularly in children. New research, generated in mice, now indicates that lithium protects nerves in the region of the brain known as the hippocampus during irradiation by promoting DNA repair, leading to the suggestion that lithium should be considered as a possible treatment to reduce the long-term neurological side effects of cranial radiation therapy, particularly in children.

Cranial radiation therapy to treat brain cancer can result in various long-term neurological side effects, particularly in children. Lithium has protective properties in the brain that make it a potential therapy for reducing these side effects; however, little is known about the mechanisms by which it protects nerves.

In a new study, Fen Xia and colleagues, at Vanderbilt University Medical Center, Nashville, present results, generated in irradiated mice, that lithium protects nerves in the region of the brain known as the hippocampus by promoting DNA repair.

Specifically, a decreased number of double-strand DNA breaks were observed in lithium-treated, irradiated mice and brain cells compared to controls. This decrease was associated with increased markers for the nonhomologous end-joining DNA repair pathway.

When this pathway was blocked in mice, lithium provided substantially less protection to the hippocampal nerve cells. The authors therefore conclude that lithium should be considered as a possible treatment to reduce the long-term neurological side effects of cranial radiation therapy, particularly in children, and that targeted therapies to enhance DNA repair may provide an avenue for future therapeutic development.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yang et al. Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK–dependent repair in mice. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI34051

Cite This Page:

Journal of Clinical Investigation. "Lithium Protects Brain Cells During Cranial Radiation." ScienceDaily. ScienceDaily, 1 April 2009. <www.sciencedaily.com/releases/2009/04/090401181219.htm>.
Journal of Clinical Investigation. (2009, April 1). Lithium Protects Brain Cells During Cranial Radiation. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2009/04/090401181219.htm
Journal of Clinical Investigation. "Lithium Protects Brain Cells During Cranial Radiation." ScienceDaily. www.sciencedaily.com/releases/2009/04/090401181219.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins