Featured Research

from universities, journals, and other organizations

Oral Rehydration Solution For Diarrhea: More Research Needed On New Formulations

Date:
April 18, 2009
Source:
Wiley - Blackwell
Summary:
Newer polymer-based formulations of oral rehydration solution given to treat diarrhea may offer some benefits over older sugar-salt formulations. But, say researchers who carried out a review of the available evidence, more research is required to establish the best treatment option.

Newer polymer-based formulations of oral rehydration solution given to treat diarrhoea may offer some benefits over older sugar-salt formulations. But, say Cochrane researchers who carried out a review of the available evidence, more research is required to establish the best treatment option.

Related Articles


Acute diarrhoea is a major cause of childhood death in developing countries. Children are treated with oral rehydration solution (ORS), which is given to help replace lost fluid and prevent further dehydration. While ORS formulations have traditionally contained sugar and salt, new formulations have been tested that replace the sugar with sugar-containing polymers from rice, wheat, sorghum, and maize.

One problem with sugar-based ORS solutions is that the sugar actively draws water from the body, making the diarrhoea worse. The sugar is also present for only a short time before it is used or voided. In contrast, the polymers release sugar slowly, lessening its ability to cause dehydration, and providing a long, low-level source of energy - a so-called 'glucose-battery'.

The review focused on 27 trials in children, five in adults and two in both. Together they included 4,214 participants and indicated that polymer-based ORS reduced the time that cholera patients suffered from diarrhoea. Polymer-based ORS also decreased the need to give patients intravenous fluid compared to previous, higher concentration sugar-salt solutions, but evidence was limited for the comparison with less concentrated salt solutions that are currently recommended.

"More trials comparing polymer-based ORS formulations to the current best agreed formula are needed," says lead researcher Germana Gregorio, who works at the Department of Pediatrics of the Philippine General Hospital at the University of the Philippines.

As Gregorio points out, however, polymer based formulations are less practical to prepare. "Glucose-based ORS requires only mixing of the contents of a sachet with boiled water, whereas rice, wheat, maize and potatoes are more tedious to prepare," she says. "And in humid countries they have to be consumed in a few hours to avoid bacterial contamination."


Story Source:

The above story is based on materials provided by Wiley - Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gregorio et al. Glucose polymer-based oral rehydration solution for treating acute watery diarrhoea. Cochrane Database of Systematic Reviews Reviews, 2009, Issue 2. Art. No.: CD006519 DOI: 10.1002/14651858.CD006519.pub2

Cite This Page:

Wiley - Blackwell. "Oral Rehydration Solution For Diarrhea: More Research Needed On New Formulations." ScienceDaily. ScienceDaily, 18 April 2009. <www.sciencedaily.com/releases/2009/04/090415074949.htm>.
Wiley - Blackwell. (2009, April 18). Oral Rehydration Solution For Diarrhea: More Research Needed On New Formulations. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2009/04/090415074949.htm
Wiley - Blackwell. "Oral Rehydration Solution For Diarrhea: More Research Needed On New Formulations." ScienceDaily. www.sciencedaily.com/releases/2009/04/090415074949.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins