Featured Research

from universities, journals, and other organizations

'Smart Bomb' Drug Delivery May Increase Effectiveness

Date:
April 25, 2009
Source:
American Association for Cancer Research
Summary:
Researchers may have found a way to combine imaging with chemotherapy in a single agent for the treatment of prostate cancer, according to new data.

Researchers may have found a way to combine imaging with chemotherapy in a single agent for the treatment of prostate cancer, according to data presented at the American Association for Cancer Research 100th Annual Meeting 2009.

Related Articles


"It's like a smart bomb, to use a military analogy," said John P. Sedelaar, Ph.D., M.D., a postdoctoral research fellow at Johns Hopkins University. "By retooling chemotherapy agents, we may be able to get more accurate treatment monitoring and follow-up."

Sedelaar said current clinical practice uses multimodality MRI to examine the urological system for diagnosing prostate cancer. This tool, however, is mostly thought of as a prostate imaging method, rather than a prostate cancer imaging method.

"An increasing number of patients have minimal prostate cancer, and opt for either very focused treatment or the watchful waiting approach," said Sedelaar. "In this environment, the need for an accurate imaging tool is paramount."

Sedelaar and colleagues designed two imaging drugs: a PSMA and a PSA-activated pro-drug. These agents are therapeutic drugs that are modified by adding a tyrosine ring for imaging.

Following administration into laboratory mice, researchers noted a measureable reduction in prostate cancer cells.

Experiments also showed that the imaging pro-drugs were cleaved and activated by PSMA or PSA, suggesting their viability as a prostate cancer imaging modality.

"Unfortunately, next to clear tumor uptake there was also uptake into liver and kidney organs. Further experiments will have to address that problem," said Sedelaar.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "'Smart Bomb' Drug Delivery May Increase Effectiveness." ScienceDaily. ScienceDaily, 25 April 2009. <www.sciencedaily.com/releases/2009/04/090421154320.htm>.
American Association for Cancer Research. (2009, April 25). 'Smart Bomb' Drug Delivery May Increase Effectiveness. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2009/04/090421154320.htm
American Association for Cancer Research. "'Smart Bomb' Drug Delivery May Increase Effectiveness." ScienceDaily. www.sciencedaily.com/releases/2009/04/090421154320.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins