Featured Research

from universities, journals, and other organizations

How An Antibody Helps The Immune System Reject Cancer

Date:
April 27, 2009
Source:
Fox Chase Cancer Center
Summary:
Researchers have shown that an engineered antibody called DTA-1 led to rejection of 50 to 60 percent of tumors in a mouse model of melanoma. The antibody allows the immune system to overcome its natural reluctance to attack tumor cells, the researchers say, and might serve to boost the effectiveness of cancer vaccines.

In concept, the human immune system has the power to destroy cancer cells with great specificity. Therefore, cancer vaccines, like vaccines against influenza or other diseases, offer the hope of enticing the immune system to recognize proteins found on the surface of cancerous cells. The reality, however, is that the immune system rarely takes the bait that these vaccines offer, and that other approaches to stimulating anti-cancer immunity are needed.

Related Articles


Now, researchers at Fox Chase Cancer Center, in collaboration with colleagues at Memorial Sloan-Kettering Cancer Center, have shown that an engineered antibody called DTA-1 led to rejection of 50 to 60 percent of tumors in a mouse model of melanoma. The antibody allows the immune system to overcome its natural reluctance to attack tumor cells, the researchers say.

"Despite the promise of cancer vaccines, it has become clear that a vaccine alone won't necessarily generate an effective immune response, in large part due to suppressive elements within the tumor," says the project's lead researcher Adam D. Cohen, M.D., an oncologist at Fox Chase. "Here we show that we can use DTA-1 to impair regulatory T cells, in effect waking the immune system to the presence of a cancer."

Cohen presented his findings at the 100th Annual Meeting of the American Association for Cancer Research, in Denver, Colorado.

DTA-1 is an antibody designed to stimulate the glucocorticoid-induced tumor necrosis factor receptor (GITR), a protein found on the surface of many T cells, including the regulatory T cells that suppress immune function and the effector T cells that help carry out an immune response. DTA-1 was developed by Shimon Sakaguchi, M.D., Ph.D., at the Institute for Frontier Medical Sciences in Kyoto, Japan. According to Cohen, their studies show that DTA-1 helps the immune system overcome its natural reluctance to attack tumor cells that it would otherwise have thought of as part of the body.

"Of course, we wouldn't want to completely shut down the immune system's ability to differentiate its own cells, which can lead to autoimmune disease," Cohen says. "Our findings suggest, however, that DTA-1 can temporarily and focally skew the ratio between regulatory and effector T cells in our favor."

According to Cohen, their findings provide further support for the continued development of GITR-targeting antibodies, either alone or in combination with cancer vaccines, as an immunotherapeutic strategy for treating cancer.

Funding for this research comes from grants from the National Cancer Institute, the Charles A. Dana Foundation, the American Society of Clinical Oncology, and philanthropic funds from Swim Across America.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "How An Antibody Helps The Immune System Reject Cancer." ScienceDaily. ScienceDaily, 27 April 2009. <www.sciencedaily.com/releases/2009/04/090422121850.htm>.
Fox Chase Cancer Center. (2009, April 27). How An Antibody Helps The Immune System Reject Cancer. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2009/04/090422121850.htm
Fox Chase Cancer Center. "How An Antibody Helps The Immune System Reject Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/04/090422121850.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins