Featured Research

from universities, journals, and other organizations

Dietary Acrylamide Not Associated With Increased Lung Cancer Risk In Men

Date:
May 5, 2009
Source:
Journal of the National Cancer Institute
Summary:
Dietary acrylamide was not associated with an increased risk of lung cancer, according to data from a large prospective case-cohort study.

Dietary acrylamide was not associated with an increased risk of lung cancer, according to data from a large prospective case-cohort study.
Credit: iStockphoto/Aleksandr Stennikov

Dietary acrylamide was not associated with an increased risk of lung cancer, according to data from a large prospective case-cohort study.

Acrylamide is formed in some starchy foods, such as potato chips and French fries, during high-temperature cooking. Epidemiological studies have found a positive association between dietary acrylamide intake and the risk of endometrial, ovarian, renal cell, and estrogen-receptor positive breast cancers.

To investigate whether dietary acrylamide intake is associated with lung cancer risk, Janneke G. F. Hogervorst, M.Sc., of Maastricht University in the Netherlands, and colleagues conducted a case-cohort study among 58,279 men and 62,573 women in the Netherlands Cohort Study on Diet and Cancer. Intake of acrylamide was estimated based on food-frequency questionnaires completed upon enrollment in the study.

After a follow-up of 13 years, 1,600 men and 295 women were diagnosed with lung cancer. When the investigators divided participants into five groups based on dietary acrylamide intake, they found no statistically significant difference in lung cancer incidence in men who consumed the highest and lowest amounts of acrylamide-containing foods. By contrast, the researchers found that women who ate the most acrylamide-containing foods had a statistically significant lower incidence of lung cancer compared with those in the group who consumed the least acrylamide-containing foods. All analyses were adjusted for smoking.

"Acrylamide intake was not associated with lung cancer risk in men but was inversely associated in women… This finding suggests that acrylamide is involved in human carcinogenesis through pathways other than genotoxicity," the authors write. They hypothesize that acrylamide may affect hormonal balances, which might explain how it could be associated with a reduction in lung cancer risk but an increase in risk of endometrial and ovarian malignancies.

In an accompanying editorial, Lorelei A. Mucci, ScD. and Hans-Olov Adami, M.D., Ph.D., of the Harvard School of Public Health in Boston, review past studies of dietary acrylamide and cancer, as well as the initial discovery of acrylamide in foods. They note that several studies have found a positive association between dietary acrylamide and some types of cancer. The editorialists also express caution about concluding that dietary acrylamide may have a protective effect in women with respect to lung cancer risk, pointing out the potential for false-positive associations.

"In our view, speculation about the potential mechanisms of the protective effect of acrylamide on lung cancer among women should await confirmation of the association in additional studies," the editorialists conclude. "Perhaps the safer conclusion we can make from the Netherlands study is that the findings do not support a positive association between acrylamide intake from diet and risk of lung cancer."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal References:

  1. Hogervorst et al. Lung Cancer Risk in Relation to Dietary Acrylamide Intake. J Natl Cancer Inst, 2009, 101: 651-662
  2. Mucci L. and Adami H. The Plight of the Potato: Is Dietary Acrylamide a Risk Factor for Human Cancer. J Natl Cancer Inst, 2009, 101: 618-621

Cite This Page:

Journal of the National Cancer Institute. "Dietary Acrylamide Not Associated With Increased Lung Cancer Risk In Men." ScienceDaily. ScienceDaily, 5 May 2009. <www.sciencedaily.com/releases/2009/04/090428162009.htm>.
Journal of the National Cancer Institute. (2009, May 5). Dietary Acrylamide Not Associated With Increased Lung Cancer Risk In Men. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2009/04/090428162009.htm
Journal of the National Cancer Institute. "Dietary Acrylamide Not Associated With Increased Lung Cancer Risk In Men." ScienceDaily. www.sciencedaily.com/releases/2009/04/090428162009.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins