Featured Research

from universities, journals, and other organizations

Acute Kidney Injury Common After Liver Transplantation

Date:
May 4, 2009
Source:
Wiley-Blackwell
Summary:
Even mild cases of acute kidney injury after liver transplantation are associated with lower survival for both the patient and the graft. With more severe injury, outcomes are even worse.

Even mild cases of acute kidney injury after liver transplantation are associated with lower survival for both the patient and the graft. With more severe injury, outcomes are even worse.

Related Articles


Acute kidney injury often occurs after liver transplantation because of blood loss or surgery-related events. Previous studies have estimated the incidence rate at 17 to 95 percent—a wide range that reveals the lack of clear diagnostic criteria. To address this problem, researchers led by Yousri Barri of Baylor University Medical Center in Texas sought to find the optimal definition for acute kidney injury after liver transplantation, and determine its impact on patients’ long-term outcomes.

They retrospectively studied patients who underwent liver transplantation at Baylor between 1997 and 2005 and applied three commonly used definitions of acute kidney injury, each based on change in serum creatinine from baseline. These were: a rise in serum creatinine of more than .5 mg/dL; a rise of more than 1.0 mg/dL; and a rise of more than 50 percent to above 2 mg/dL. The outcomes for each group of patients were compared to those from a control group that did not have kidney injury.

The majority of liver transplant recipients experienced some degree of acute kidney injury. About 78 percent of the transplant recipients had a rise in creatinine or more than 0.5 mg/dL from baseline, considered mild in severity. About 46 percent had a moderate creatinine increase of 1.0 mg/dL or more, while 14 percent had a marked creatinine increase of 50 percent or more to above 2.0 mg/dL.

“Even mild acute kidney injury defined as rise in serum creatinine of >0.5 mg/dL was associated with reduced patient and graft survival,” the authors report. They suggest that this sensitive definition, which captures a large majority of liver transplant recipients, deserves attention and strategies for prevention.

However, the strictest definition of acute kidney injury was associated with the worst outcomes, including higher incidence of cardiovascular events and end-stage renal disease.

“This study shows that acute kidney injury, appropriately defined, has an important impact on long-term renal function and patient and graft survival post-liver transplantation,” the authors conclude. “Whether acute kidney injury is the direct cause or simply associated with poor outcome will need further study.”

An accompanying editorial by Connie Davis of the University of Washington Medical Center applauds the focus on “a very simple easily available measure, the degree of change in serum creatinine.” Barri and colleagues revealed a clear association between this measure and worse outcomes within a few years of the transplant.

“It is time to give kidney dysfunction a clear identity and treatment strategy in the setting of liver transplantation,” she concludes.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal References:

  1. Barri, Yousri; Sanchez, Edmund; Jennings, Linda; Melton, Larry; Hays, Steven; Levy, Marlon; Klintmalm, Goran. Acute Kidney Injury (AKI) Following Liver Transplantation: Definition and Outcome. Liver Transplantation, May 2009
  2. Davis, Connie. What%u2019s in a name? AKI. Liver Transplantation, May 2009

Cite This Page:

Wiley-Blackwell. "Acute Kidney Injury Common After Liver Transplantation." ScienceDaily. ScienceDaily, 4 May 2009. <www.sciencedaily.com/releases/2009/05/090504122109.htm>.
Wiley-Blackwell. (2009, May 4). Acute Kidney Injury Common After Liver Transplantation. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2009/05/090504122109.htm
Wiley-Blackwell. "Acute Kidney Injury Common After Liver Transplantation." ScienceDaily. www.sciencedaily.com/releases/2009/05/090504122109.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Microsoft Launches Fitness Band After Accidental Reveal

Microsoft Launches Fitness Band After Accidental Reveal

Newsy (Oct. 30, 2014) Microsoft accidentally revealed its upcoming fitness band on Wednesday, so the company went ahead and announced it. Video provided by Newsy
Powered by NewsLook.com
Bracing to Meet a Killer: Aid Workers Prep for Ebola in Geneva

Bracing to Meet a Killer: Aid Workers Prep for Ebola in Geneva

AFP (Oct. 30, 2014) At the International Federation of Red Cross and Red Crescent Societies, around 30 doctors, nurses, lab technicians and water and sanitation workers are gathered for a crash-course in how to safely deal Ebola. Duration: 01:31 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins