Featured Research

from universities, journals, and other organizations

Hypothyroidism In Women Associated With Liver Cancer

Date:
May 8, 2009
Source:
Wiley-Blackwell
Summary:
Women with a history of hypothyroidism face a significantly higher risk of developing liver cancer.

Related Articles


Women with a history of hypothyroidism face a significantly higher risk of developing liver cancer, according to a new study.

Hypothyroidism is the most common thyroid disorder among U.S. adults, affecting between 8 and 12 percent of the U.S. population, and more women than men. The condition can cause hyperlipidemia and weight gain and may play a role in the development of nonalcoholic steatohepatitis which can progress to more severe liver disease. Studies have also suggested a clinical association between hypothyroidism and hepatitis C, which is contributing to the country’s rising rate of liver cancer.

Researchers, led by Manal Hassan of Anderson Cancer Center at the University of Texas, designed a case-control study to better understand the association between hypothyroidism and the development of liver cancer, also known as hepatocellular carcinoma (HCC), in the U.S.

They included 420 patients with liver cancer and 1,104 healthy controls. From each subject, the researchers gathered demographic data and information about liver cancer risk factors, like smoking, alcohol consumption and family cancer history. The participants were also asked about their history of thyroid conditions and obesity. They provided blood samples that were tested for hepatitis B and hepatitis C.

About 15 percent of the liver cancer patients had a history of thyroid disease, compared to about 12 percent of the healthy controls. Subjects with a history of hypothyroidism had twice the risk of liver cancer; however the relationship was only significant for females.

Women who had a prior history of hypothyroidism for more than 10 years had a threefold higher risk of liver cancer compared to women without a history of thyroid disorders. Adjusting for obesity did not change the association.

“Whether and why hypothyroidism causes HCC is not clear,” the authors write. “However, the association between hypothyroidism and NASH can be explained by the underlying hyperlipidemia, decreased fatty acid oxidation insulin resistance and lipid peroxidation in patients with hypothyroidism.” And these conditions may make the patient susceptible to HCC development.

“Further studies among different populations are warranted to confirm the association between hypothyroidism and HCC and to identify the underlying biological mechanisms and the genetic predisposition factors that may contribute to susceptibility to HCC development in the presence of thyroid disorders,” the authors conclude.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hassan, Manal; Kaseb, Ahmed; Li, Donghui; Patt, Yehuda; Vauthey, Jean-Nicolas; Thomas, Melanie; Curley, Steven A.; Spitz, Margaret; Sherman, Steven; Abdalla, Eddie; Davila, Marta; Lozano, Richard; Hassan, Deena; Chan, Wenyaw; Brown, Thomas; Abbruzzese, James. Association Between Hypothyroidism and Hepatocellular Carcinoma: USA Case-Control Study. Hepatology, May 2009

Cite This Page:

Wiley-Blackwell. "Hypothyroidism In Women Associated With Liver Cancer." ScienceDaily. ScienceDaily, 8 May 2009. <www.sciencedaily.com/releases/2009/05/090504122115.htm>.
Wiley-Blackwell. (2009, May 8). Hypothyroidism In Women Associated With Liver Cancer. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2009/05/090504122115.htm
Wiley-Blackwell. "Hypothyroidism In Women Associated With Liver Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/05/090504122115.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins