Featured Research

from universities, journals, and other organizations

Infants' Pain Response To Immunization Varies Based On Which Vaccine Is First

Date:
May 10, 2009
Source:
JAMA and Archives Journals
Summary:
Infants who receive the pneumococcal conjugate vaccine following the combination vaccine for diphtheria, polio, tetanus, pertussis and Haemophilus influenzae type b appear to experience less pain than those who are immunized in the opposite order, according to a new article.

Infants who receive the pneumococcal conjugate vaccine (PCV) following the combination vaccine for diphtheria, polio, tetanus, pertussis and Haemophilus influenzae type b (DPTaP-Hib vaccine) appear to experience less pain than those who are immunized in the opposite order, according to a new article.

Injections are the most painful common medical procedure conducted in childhood, according to background information in the article. "Multiple injections are routinely administered during a single visit to a physician," the authors write. "Because some vaccines cause more pain than others, the order in which they are given may affect the overall pain experience." In a recent study of U.S. pediatricians, more than 90 percent reported at least one parent in their practice had refused to have a child vaccinated in the previous year, most commonly due to the pain caused by multiple vaccines. Therefore, reducing the pain associated with vaccines could increase immunization rates and prevent a resurgence of infectious diseases.

Moshe Ipp, M.B.B.Ch., of The Hospital for Sick Children, Toronto, Ontario, Canada, and colleagues studied 120 healthy infants age 2 to 6 months undergoing routine immunization at an outpatient pediatric clinic in 2006 or 2007. Sixty infants received the PCV before the DPTaP-Hib vaccine, while 60 received the DPTaP-Hib vaccine first. The procedure was videotaped and pain was assessed on a scale that considered the infant's facial expression, crying and body movements after vaccination. Parents were also asked to rate their children's pain levels on a scale of zero to 10.

"Infant pain response during routine intramuscular vaccine injection was affected by the order of administration of the vaccine," the authors write. "Infants given the less painful DPTaP-Hib vaccine first followed by the more painful PCV experienced less pain overall when compared with those given the vaccines in the reverse order. In addition, pain increased from the first to the second injection, regardless of the order of vaccine injection."

These data suggest that when two immunizations are given, the least painful vaccine should be administered first, the authors note. Giving the more painful injection first may focus the infant's attention on the procedure and activate pain processing centers in the brain, resulting in a more intense pain signal in response to any shots given afterward.

"Steps to minimize vaccine-related pain reduces the pain experienced by the child and improves the immunization experience of parents and health care workers," the authors conclude. "Varying the order of vaccine administration to reduce pain is a strategy that is simple and effective, cost-free and easily incorporated into clinical practice. In considering methods of reducing pain with vaccination, vaccine manufacturers must play a more integral role in attempting to produce vaccine formulations that are less painful."

Editor's Note: This study was funded by an unrestricted grant from Sanofi Pasteur, Toronto, Ontario, Canada. Co-author Dr. Taddio is supported by a New Investigator Award by the Canadian Institutes of Health Research. The Pediatric Outcomes Research Team is supported by a grant from The Hospital for Sick Children Foundation.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ipp et al. Order of Vaccine Injection and Infant Pain Response. Archives of Pediatrics and Adolescent Medicine, 2009; 163 (5): 469 DOI: 10.1001/archpediatrics.2009.35

Cite This Page:

JAMA and Archives Journals. "Infants' Pain Response To Immunization Varies Based On Which Vaccine Is First." ScienceDaily. ScienceDaily, 10 May 2009. <www.sciencedaily.com/releases/2009/05/090504161612.htm>.
JAMA and Archives Journals. (2009, May 10). Infants' Pain Response To Immunization Varies Based On Which Vaccine Is First. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2009/05/090504161612.htm
JAMA and Archives Journals. "Infants' Pain Response To Immunization Varies Based On Which Vaccine Is First." ScienceDaily. www.sciencedaily.com/releases/2009/05/090504161612.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins