Featured Research

from universities, journals, and other organizations

Non-wovens As Scaffolds For Artificial Tissue

Date:
May 21, 2009
Source:
Fraunhofer-Gesellschaft
Summary:
In future, cartilage, tendon and blood vessel tissue will be produced in the laboratory, with cells being grown on a porous frame, such as non-wovens. A new software program helps to characterize and optimize the non-wovens.

Non-wovens as scaffolds for artificial tissue.
Credit: Image courtesy of Fraunhofer-Gesellschaft

When someone’s knee hurts with every step it’s a sign that the cartilage has been so badly damaged that the bones rub together when walking. Medical scientists are developing a technique to produce cartilage tissue artificially so that patients with such knee problems can walk free of pain again.

Related Articles


The aim is also to make tendons and blood vessels in the laboratory. The research scientists place cells on a porous scaffold material, for example a non-woven made of polymer fibers. The cells can then grow on this frame and form tissue.

Whether the cells will grow properly into tissue, however, depends on many factors. For instance, the cells only form cartilage if they are subjected to loads comparable with those in the body. To form cartilage the tissue needs to experience the pressure applied by every step. By contrast, blood vessel tissue needs the pulsation of the blood. The scientists reproduce these loads in the cell culture. When the artificial cartilage is inserted in the patient’s knee the supporting scaffold is gradually resorbed and only the cartilage tissue remains.

While it is quite easy to produce npn-wovens from thin polymer fibers, it is difficult to describe these materials experimentally and theoretically. What forces do the cells experience when the non-woven is pulled or when a liquid passes through the fibre network? How do cells penetrate the non-woven? How do liquids permeate the non-woven?

Research scientists at the Fraunhofer Institute for Mechanics of Materials IWM in Freiburg and Halle have developed a simulation model which answers these questions and characterizes the fleeces. “The simulation reproduces the mechanical properties of the fleeces and the transport processes – the software can therefore also calculate how nutrients are transported to the cells and metabolic products are transported away from the cells when a liquid flows by,” explains Dr. Raimund Jaeger, group manager at the IWM. “Understanding these processes can be helpful for cell culture.” To produce the model, the research scientists initially studied the mechanical properties of the individual polymer fibers and for this purpose developed a special apparatus. On a silicon chip measuring one square centimeter, the scientists in Halle etched approximately 50 “microtesting machines”. They then placed and fastened the fibers over the testing machines. Under the microscope the researchers were able to observe how the fibers behave when they are pulled, how far they stretch and when they snap.

As fiber-like structures are frequently encountered in nature and technology, suitable experimental techniques and simulation methods have a wide range of applications.


Story Source:

The above story is based on materials provided by Fraunhofer-Gesellschaft. Note: Materials may be edited for content and length.


Cite This Page:

Fraunhofer-Gesellschaft. "Non-wovens As Scaffolds For Artificial Tissue." ScienceDaily. ScienceDaily, 21 May 2009. <www.sciencedaily.com/releases/2009/05/090513091520.htm>.
Fraunhofer-Gesellschaft. (2009, May 21). Non-wovens As Scaffolds For Artificial Tissue. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2009/05/090513091520.htm
Fraunhofer-Gesellschaft. "Non-wovens As Scaffolds For Artificial Tissue." ScienceDaily. www.sciencedaily.com/releases/2009/05/090513091520.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Building Google Into Cars

Building Google Into Cars

Reuters - Business Video Online (Dec. 19, 2014) Google's next Android version could become the standard that'll power your vehicle's entertainment and navigation features, Reuters has learned. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
AP Review: Nikon D750 and GoPro Hero 4

AP Review: Nikon D750 and GoPro Hero 4

AP (Dec. 19, 2014) What to buy an experienced photographer or video shooter? There is some strong gear on the market from Nikon and GoPro. The AP's Ron Harris takes a closer look. (Dec. 19) Video provided by AP
Powered by NewsLook.com
Obama: Better Ways to Create Jobs Than Keystone Pipeline

Obama: Better Ways to Create Jobs Than Keystone Pipeline

AFP (Dec. 19, 2014) US President Barack Obama says that construction of the Keystone pipeline would have 'very little impact' on US gas prices and believes there are 'more direct ways' to create construction jobs. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins