Featured Research

from universities, journals, and other organizations

Genes That Influence Start Of Menstruation Identified For First Time

Date:
May 21, 2009
Source:
The Peninsula College of Medicine and Dentistry
Summary:
Researchers from the Peninsula Medical School, along with collaborators from research institutions across Europe and the United States, have for the first time identified two genes that are involved in determining when girls begin menstruation.

Two genes clarify the genetic control of female sexual maturation, and point to regulatory mechanisms involved in human growth and development.

Related Articles


Researchers from the Peninsula Medical School, along with collaborators from research institutions across Europe and the United States, have for the first time identified two genes that are involved in determining when girls begin menstruation. 

The findings of the study could have ramifications for normal human growth and weight too, because early-age menstruation is also associated with shorter stature and increased body weight. In general, girls who achieve menstruation earlier in life tend to have greater body mass index (BMI) and a higher ratio of fat compared to those who begin menstruation later.

The study carried out an analysis of 17,510 women across eight different international population-based sources. This number included women of European descent who reported the age at which they reached menstruation of between nine and 17 years.

The two genes identified were on chromosomes nine and six. One in 20 females carry two copies of each of the gene variations which result in menstruation starting earlier, and they will start menstruating approximately four and half months earlier than those with no copies of the gene variants.

Dr Anna Murray from the Peninsula Medical School, commented: "This study provides the first evidence that common genetic variants influence the time at which women reach sexual maturation. Our findings also indicate a genetic basis for the associations between early menstruation and both height and BMI."

She added: "The study takes us nearer to understanding the biology of the processes involved in puberty and early growth and to understand what constitutes 'normal' in growth and development."

Fellow author John Perry, also from the Peninsula Medical School, added: "Understanding the biological mechanisms behind reproductive lifespan may also help inform us about associated diseases that affect a lot of women as they get older, including diabetes, heart disease and breast cancer."


Story Source:

The above story is based on materials provided by The Peninsula College of Medicine and Dentistry. Note: Materials may be edited for content and length.


Journal Reference:

  1. John R B Perry, Lisette Stolk, Nora Franceschini, Kathryn L Lunetta, Guangju Zhai, Patrick F McArdle, Albert V Smith, Thor Aspelund, Stefania Bandinelli, Eric Boerwinkle, Lynn Cherkas, Gudny Eiriksdottir, Karol Estrada, Luigi Ferrucci, Aaron R Folsom, Melissa Garcia, Vilmundur Gudnason, Albert Hofman, David Karasik, Douglas P Kiel, Lenore J Launer, Joyce van Meurs, Michael A Nalls, Fernando Rivadeneira, Alan R Shuldiner, Andrew Singleton, Nicole Soranzo, Toshiko Tanaka, Jenny A Visser, Michael N Weedon, Scott G Wilson, Vivian Zhuang, Elizabeth A Streeten, Tamara B Harris, Anna Murray, Tim D Spector, Ellen W Demerath, Andrι G Uitterlinden & Joanne M Murabito. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics, May 17, 2009 DOI: 10.1038/ng.386

Cite This Page:

The Peninsula College of Medicine and Dentistry. "Genes That Influence Start Of Menstruation Identified For First Time." ScienceDaily. ScienceDaily, 21 May 2009. <www.sciencedaily.com/releases/2009/05/090517143215.htm>.
The Peninsula College of Medicine and Dentistry. (2009, May 21). Genes That Influence Start Of Menstruation Identified For First Time. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2009/05/090517143215.htm
The Peninsula College of Medicine and Dentistry. "Genes That Influence Start Of Menstruation Identified For First Time." ScienceDaily. www.sciencedaily.com/releases/2009/05/090517143215.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins