Featured Research

from universities, journals, and other organizations

Novel Mechanism Of Action Of Corticosteroids In Allergic Diseases

Date:
May 25, 2009
Source:
Public Library of Science
Summary:
New research may explain the effectiveness of common treatments for allergic inflammation and may point the way to targets for new treatments for allergic diseases.

Research by Peter Barnes (Imperial College, London) and colleagues may explain the effectiveness of common treatments for allergic inflammation and may point the way to targets for new treatments for allergic diseases, according to a new study.

Allergic diseases – which affect about 50 million people a year in the US alone – are triggered when the immune system responds to a normally harmless material by activating a specific type of T lymphocyte called a T helper-2 cell (Th2). The Th2 cells make three cytokines, which are responsible for the inflammation associated with allergies. Corticosteroids are often used to treat allergic inflammation but it is not well understood how these corticosteroids work to inhibit the expression of Th2 cytokines.

Using laboratory experiments and tests in seven patients with mild asthma, Peter Barnes and colleagues suggest that corticosteroids inhibit the expression of Th2 cytokines and thus reduce allergic inflammation through two interacting mechanisms which both prevent the nuclear translocation of GATA-3, a key regulator of cytokine expression. Firstly, they suggest that corticosteroids compete with GATA-3 for binding to the nuclear import protein importin-α. Secondly, they suggest that corticosteroids prevent the phosphorylation of GATA-3, further preventing GATA-3 from binding to importin-α.

According to the authors, "This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases", although further experiments are needed to show that the lymphocytes at the sites of allergic infection respond to corticosteroids in the same way as lymphocytes in the blood. In addition, these findings suggest that interaction between phosphorylated GATA-3 and importin-α may represent an important target for the development of new therapies for the treatment of allergic diseases.

This study was supported by a grant from the Medical Research Council and a non-restrictive grant from GlaxoSmithKline. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maneechotesuwan et al. Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease. PLoS Medicine, 2009; 6 (5): e1000076 DOI: 10.1371/journal.pmed.1000076

Cite This Page:

Public Library of Science. "Novel Mechanism Of Action Of Corticosteroids In Allergic Diseases." ScienceDaily. ScienceDaily, 25 May 2009. <www.sciencedaily.com/releases/2009/05/090518213935.htm>.
Public Library of Science. (2009, May 25). Novel Mechanism Of Action Of Corticosteroids In Allergic Diseases. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2009/05/090518213935.htm
Public Library of Science. "Novel Mechanism Of Action Of Corticosteroids In Allergic Diseases." ScienceDaily. www.sciencedaily.com/releases/2009/05/090518213935.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins