Featured Research

from universities, journals, and other organizations

How Viral Infection Can Protect From Type 1 Diabetes

Date:
May 28, 2009
Source:
Journal of Clinical Investigation
Summary:
Type 1 diabetes is caused by immune system–mediated destruction of insulin-producing beta-cells in the pancreas. It is known that infection with a virus can induce an immune response that damages beta-cells or a response that protects an individual from type 1 diabetes.

Type 1 diabetes is caused by immune system–mediated destruction of insulin-producing beta-cells in the pancreas. It is known that infection with a virus can induce an immune response that damages beta-cells or a response that protects an individual from type 1 diabetes.

Related Articles


However, the mechanisms by which viruses can have such divergent effects are not well understood. A team of researchers, at La Jolla Institute for Allergy & Immunology, La Jolla, has now provided some insight into this issue by showing that in a mouse model of type 1 diabetes, viruses that do not damage beta-cells provide protection from the autoimmune disease.

The team, led by Christophe Filippi and Matthias von Herrath, observed that infection with either Coxsackie virus B3 or lymphocytic choriomeningitis virus delayed the onset and reduced the incidence of disease in the mouse model of type 1 diabetes. Further analysis revealed a synergistic underlying protective mechanism: levels of the protein PD-L1 were transiently upregulated on immune cells known as lymphoid cells, and there was an increase in the number of CD4+CD25+ Tregs and an increase in their ability to produce the immunomodulatory factor TGF-beta.

In an accompanying commentary, Terry Strom, at Beth Israel Deaconess Medical Center, Boston, discusses these mechanisms in further detail.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Christophe Filippi et al. Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. Journal of Clinical Investigation, May 26, 2009
  2. Terry Strom. Can childhood viral infection protect from type 1 diabetes? Journal of Clinical Investigation, May 26, 2009

Cite This Page:

Journal of Clinical Investigation. "How Viral Infection Can Protect From Type 1 Diabetes." ScienceDaily. ScienceDaily, 28 May 2009. <www.sciencedaily.com/releases/2009/05/090526171807.htm>.
Journal of Clinical Investigation. (2009, May 28). How Viral Infection Can Protect From Type 1 Diabetes. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/05/090526171807.htm
Journal of Clinical Investigation. "How Viral Infection Can Protect From Type 1 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2009/05/090526171807.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins