Featured Research

from universities, journals, and other organizations

How Viral Infection Can Protect From Type 1 Diabetes

Date:
May 28, 2009
Source:
Journal of Clinical Investigation
Summary:
Type 1 diabetes is caused by immune system–mediated destruction of insulin-producing beta-cells in the pancreas. It is known that infection with a virus can induce an immune response that damages beta-cells or a response that protects an individual from type 1 diabetes.

Type 1 diabetes is caused by immune system–mediated destruction of insulin-producing beta-cells in the pancreas. It is known that infection with a virus can induce an immune response that damages beta-cells or a response that protects an individual from type 1 diabetes.

Related Articles


However, the mechanisms by which viruses can have such divergent effects are not well understood. A team of researchers, at La Jolla Institute for Allergy & Immunology, La Jolla, has now provided some insight into this issue by showing that in a mouse model of type 1 diabetes, viruses that do not damage beta-cells provide protection from the autoimmune disease.

The team, led by Christophe Filippi and Matthias von Herrath, observed that infection with either Coxsackie virus B3 or lymphocytic choriomeningitis virus delayed the onset and reduced the incidence of disease in the mouse model of type 1 diabetes. Further analysis revealed a synergistic underlying protective mechanism: levels of the protein PD-L1 were transiently upregulated on immune cells known as lymphoid cells, and there was an increase in the number of CD4+CD25+ Tregs and an increase in their ability to produce the immunomodulatory factor TGF-beta.

In an accompanying commentary, Terry Strom, at Beth Israel Deaconess Medical Center, Boston, discusses these mechanisms in further detail.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Christophe Filippi et al. Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. Journal of Clinical Investigation, May 26, 2009
  2. Terry Strom. Can childhood viral infection protect from type 1 diabetes? Journal of Clinical Investigation, May 26, 2009

Cite This Page:

Journal of Clinical Investigation. "How Viral Infection Can Protect From Type 1 Diabetes." ScienceDaily. ScienceDaily, 28 May 2009. <www.sciencedaily.com/releases/2009/05/090526171807.htm>.
Journal of Clinical Investigation. (2009, May 28). How Viral Infection Can Protect From Type 1 Diabetes. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2009/05/090526171807.htm
Journal of Clinical Investigation. "How Viral Infection Can Protect From Type 1 Diabetes." ScienceDaily. www.sciencedaily.com/releases/2009/05/090526171807.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins