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Toward New Drugs That Turn Genes On And Off

Date:
June 21, 2009
Source:
American Chemical Society
Summary:
Scientists are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, cancer and a range of other disorders. Acting like an "on-off switch," the medications might ratchet up the production of proteins in genes working at abnormally low levels or shut off genes producing an abnormal protein linked to disease.

Scientists found a group of molecules that act like an "on-off switch" and could be used to develop medicines against various diseases.
Credit: The American Chemical Society

Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, cancer and a range of other disorders. Acting like an "on-off switch," the medications might ratchet up the production of proteins in genes working at abnormally low levels or shut off genes producing an abnormal protein linked to disease.

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In the study, Anna K. Mapp and colleagues discusses molecules that cause genes to be active and churn out proteins — so-called transcriptional activators. That's because they control a key process known as transcription, in which instructions coded in genes produce proteins. Malfunctions in these activators could lead to altered transcription patterns that lead to disease. For example, variations in the tumor suppressor gene p53 are found in more than half of all human cancers.

Mapp describes discovery of a group of molecules that could be used to help scientists better understand transcription. Known as activator artificial transcriptional activation domains, these small molecules mimic natural activators and could provide insights on how mistakes in gene regulation result in various diseases. "Evidence suggests that these small molecules mimic the function and mechanism of their natural counterparts and present a framework for the broader development of small molecule transcriptional switches," Mapp states.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Buhrlage et al. Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors. ACS Chemical Biology, 2009; 4 (5): 335 DOI: 10.1021/cb900028j

Cite This Page:

American Chemical Society. "Toward New Drugs That Turn Genes On And Off." ScienceDaily. ScienceDaily, 21 June 2009. <www.sciencedaily.com/releases/2009/06/090608101607.htm>.
American Chemical Society. (2009, June 21). Toward New Drugs That Turn Genes On And Off. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2009/06/090608101607.htm
American Chemical Society. "Toward New Drugs That Turn Genes On And Off." ScienceDaily. www.sciencedaily.com/releases/2009/06/090608101607.htm (accessed February 28, 2015).

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