Featured Research

from universities, journals, and other organizations

Reengineering A Food Poisoning Microbe To Carry Medicines And Vaccines

Date:
June 16, 2009
Source:
American Chemical Society
Summary:
Scientists have used genetic engineering to tame one of the most deadly food poisoning microbes and turn it into a potential new way of giving patients medicine and vaccines in pills rather than injections.

Scientists have used genetic engineering to tame one of the most deadly food poisoning microbes and turn it into a potential new way of giving patients medicine and vaccines in pills rather than injections.

Colin Pouton and colleagues note that patients by far prefer pills and capsules to the discomfort and inconvenience of injections. But many medicines and vaccines cannot be given by mouth because they would be destroyed by stomach acid without being absorbed into the bloodstream. One promising approach is to use live bacteria, which can survive those harsh conditions and pass easily from the GI tract into the blood.

The scientists describe development of a new strain of Listeria monocytogenes, bacteria that normally cause food poisoning, but which have been genetically engineered to be harmless. Instead of causing disease, the new microbes can be loaded with medicine or vaccine, and deliver that beneficial cargo by "infecting" cells.

After entering cells, the bacteria burst and die, leading to Pouton's term "suicidal strain" for the microbes. The researchers demonstrated that engineered bacteria containing a test protein could successfully penetrate a group of intestinal cells grown in the lab and deliver the protein inside the cells while leaving the cells unharmed. The findings suggest that the approach could potentially work in humans, the researchers say.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kuo et al. A Stably Engineered, Suicidal Strain of Listeria monocytogenes Delivers Protein and/or DNA to Fully Differentiated Intestinal Epithelial Monolayers. Molecular Pharmaceutics, 2009; 090526130050086 DOI: 10.1021/mp800153u

Cite This Page:

American Chemical Society. "Reengineering A Food Poisoning Microbe To Carry Medicines And Vaccines." ScienceDaily. ScienceDaily, 16 June 2009. <www.sciencedaily.com/releases/2009/06/090615093923.htm>.
American Chemical Society. (2009, June 16). Reengineering A Food Poisoning Microbe To Carry Medicines And Vaccines. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2009/06/090615093923.htm
American Chemical Society. "Reengineering A Food Poisoning Microbe To Carry Medicines And Vaccines." ScienceDaily. www.sciencedaily.com/releases/2009/06/090615093923.htm (accessed October 20, 2014).

Share This



More Plants & Animals News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Rare Lion Cubs Make Debut at Belgrade Zoo

Raw: Rare Lion Cubs Make Debut at Belgrade Zoo

AP (Oct. 17, 2014) Two white lion cubs were born in Belgrade zoo three weeks ago. White lions are a rare mutation of a species found in South Africa and some cultures consider them divine. (Oct. 17) Video provided by AP
Powered by NewsLook.com
The Best Foods To Boost Your Mood

The Best Foods To Boost Your Mood

Buzz60 (Oct. 17, 2014) Feeling down? Reach for the refrigerator, not the medicine cabinet! TC Newman (@PurpleTCNewman) shares some of the best foods to boost your mood. Video provided by Buzz60
Powered by NewsLook.com
Sweet Times for Hard Cider Makers

Sweet Times for Hard Cider Makers

AP (Oct. 16, 2014) With hard cider making a hardcore comeback across the country, craft makers are trying to keep up with demand and apple growers are tapping a juicy new revenue stream. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Meet Garfi the Angry Cat

Meet Garfi the Angry Cat

Buzz60 (Oct. 16, 2014) Garfi is one frowny, feisty feline - downright angry! Ko Im (@koimtv) introduces us to the latest animal celebrity taking over the Internet. You can follow more of Garfi's adventures on Twitter (@MeetGarfi) and Facebook (Garfi). Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins