Featured Research

from universities, journals, and other organizations

Knee Replacements: Pinpointing The Cause Of Infection

Date:
June 29, 2009
Source:
Society of Nuclear Medicine
Summary:
A new study reveals that PET scans accurately detect infections in prosthetic knee joints more than 90 percent of the time.

A new study reveals that PET scans accurately detect infections in prosthetic knee joints more than 90 percent of the time, according to researchers at the SNM's 56th Annual Meeting. The findings could represent a significant breakthrough in the treatment of patients who undergo joint replacements. Joint replacements are prone to a number of complications following implantation.

"Infections following joint replacement surgery are very serious, very common and very difficult to distinguish from other problems such as loosening of the prosthetic," said Abass Alavi, professor of Radiology at the University of Pennsylvania, Philadelphia, and the principal investigator of the study. "Our study shows that no other diagnostic tool comes close to PET in accurately diagnosing infection with minimal discomfort for patients. What's more, the broader implication is that PET could eventually be used to successfully detect infections and inflammation for other conditions."

It is estimated that more than one million joint replacements are performed in the United States each year. Infections following implant procedures are difficult to fight because the immune system is unable to destroy bacteria that live on the implanted material. Even after treatment with strong antibiotics, the infections can persist. As a result, it is often necessary to remove prosthetic joints if they become infected.

Accurately determining whether pain in a prosthetic joint is indeed an infection can be difficult. Physicians often have to make difficult decisions to operate without accurate information on whether an infection is occurring. The most common technique used to determine infection is the white blood cell count; however, the test is only about 50 percent accurate in determining infections, is at least two times more costly than PET imaging and takes longer to provide results.

In the study, 80 patients who were experiencing painful knee symptoms underwent FDG-PET imaging after clinical evaluation and laboratory data were inconclusive for infection. Of these patients, 50 were available for full follow-up. Clinical outcomes were determined via surgical, microbiological and other clinical indicators. PET images were interpreted to indicate infection if there was increased FDG uptake at the bone-prosthesis site.

Overall, FDG-PET imaging was 92 percent accurate, correctly diagnosing eight of the nine cases of infection and identifying the absence of infection in 38 of 41 cases.

Scientific Paper 1349: A. Nawaz, J. Parvizi, H. Zhuang, D. Torigian, A. Alavi, Division of Nuclear Medicine, University of Pennsylvania, Philadelphia, and Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, "Diagnostic performance of FDG-PET in differentiating septic from aseptic painful knee prostheses," SNM's 56th Annual Meeting, June 13–17, 2009.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "Knee Replacements: Pinpointing The Cause Of Infection." ScienceDaily. ScienceDaily, 29 June 2009. <www.sciencedaily.com/releases/2009/06/090615093929.htm>.
Society of Nuclear Medicine. (2009, June 29). Knee Replacements: Pinpointing The Cause Of Infection. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/06/090615093929.htm
Society of Nuclear Medicine. "Knee Replacements: Pinpointing The Cause Of Infection." ScienceDaily. www.sciencedaily.com/releases/2009/06/090615093929.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins