ScienceDaily (June 21, 2009) — UBC researchers have created the world's first animal laboratory experiment to successfully model human gambling. The advance will help scientists develop and test new treatments for gambling addictions, a devastating condition that affects millions worldwide.

In addition to showing that rats can "play the odds," the study finds that gambling decisions can be impaired or improved with drugs that affect brain dopamine and serotonin levels suggesting that these neurotransmitters may moderate gambling behaviour.

"For most individuals, gambling is enjoyable and harmless, but for others, it is as destructive as being addicted to drugs," says Catharine Winstanley, an assistant professor in UBC's Dept. of Psychology, whose study was published June 17 in the Nature journal Neuropsychopharmacology.

"This new model is an important next step because the neurobiological basis of gambling is still poorly understood and few treatment options exist," adds Winstanley, noting that gamblers experience higher rates of divorce, suicide and crime than non-gamblers. "It brings us a step closer to the goal of drug-based treatments for people suffering from gambling disorders."

For the study, rats had a limited amount of time in which to choose between four gambling options which were associated with the delivery of different numbers of sugar pellets. If the animals won the gamble, they received the associated reward. However, if they lost, they experienced a time-out period during which reward could not be earned.

High-risk options offered more potential sugar pellets but also the possibility of more frequent and longer timeouts. Rats learned how to be successful gamblers, selecting the option with the optimum level of risk and reward to maximize their sugar pellet profits.

The study found that rodents treated with drugs that reduced their levels of serotonin levels – associated with impulse control in humans –dramatically reduced their ability to play the odds. A drug that reduced dopamine levels – associated with pleasure in humans – improved their ability to optimize profits. The findings are consistent with recent clinical findings in humans, helping to validate the technique as a model for studying human gambling behaviours.

"We hope this will speed up the development of gambling treatments for humans by giving us a working model to explore drugs and therapies," says Winstanley.

In future studies, Winstanley says she will seek to replicate other aspects of human gambling behaviours, including "loss-chasing" – when a gambler follows a loss with a high-risk gamble – and the "near-miss effect," when a near-win motivates individuals to continue gambling.

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Adapted from materials provided by University of British Columbia.

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