Featured Research

from universities, journals, and other organizations

Adding SNPs To Breast Cancer Risk Model Does Not Increase Accuracy Meaningfully

Date:
June 17, 2009
Source:
Journal of the National Cancer Institute
Summary:
Adding genotypes for seven single-nucleotide polymorphisms (SNPs) to the Breast Cancer Risk Assessment Tool (BCRAT) provided only a small improvement in the accuracy of the tool, according to a new study.

Adding genotypes for seven single-nucleotide polymorphisms (SNPs) to the Breast Cancer Risk Assessment Tool (BCRAT) provided only a small improvement in the accuracy of the tool, according to a new study.

Previous research had recommended a comparison of BCRAT, commonly known as the Gail Model, and BCRATplus7, which includes the seven SNPs associated with breast cancer.

Based on that recommendation, Mitchell H. Gail, of the Division of Cancer Epidemiology and Genetics, National Cancer Institute in Bethesda, Md., investigated four medically important applications that are based on risks and benefits to compare the performance of BCRAT with BCRATplus7. The applications were used to decide which women could benefit from tamoxifen to prevent breast cancer; which should have screening mammography; assessing the extent of reclassification of breast cancer risk; and allocating access to screening mammography under cost constraints.

Gail found that for all applications, the value added with BCRATplus7 compared with BCRAT was very small.

"In view of these uncertainties and the small improvements from BCRATplus7 in these applications, further studies are needed to validate models with SNPs and to assess how much they improve performance over simpler models," the author writes.

This research was published in the Journal of the National Cancer Institute on June 17, 2009.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Adding SNPs To Breast Cancer Risk Model Does Not Increase Accuracy Meaningfully." ScienceDaily. ScienceDaily, 17 June 2009. <www.sciencedaily.com/releases/2009/06/090617191420.htm>.
Journal of the National Cancer Institute. (2009, June 17). Adding SNPs To Breast Cancer Risk Model Does Not Increase Accuracy Meaningfully. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2009/06/090617191420.htm
Journal of the National Cancer Institute. "Adding SNPs To Breast Cancer Risk Model Does Not Increase Accuracy Meaningfully." ScienceDaily. www.sciencedaily.com/releases/2009/06/090617191420.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins