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What Is The Risk Of Obesity While Taking Antidepressant Drugs?

Date:
June 30, 2009
Source:
Journal Of Psychotherapy And Psychosomatics
Summary:
Major depressive episode (MDE) does not appear to increase the risk of obesity. The cross-sectional associations that have been reported in this study, albeit inconsistently, in the literature probably represent an effect of obesity on MDE risk. Pharmacologic treatment with antidepressants may be associated with an increased risk of obesity, and strategies to offset this risk may be useful in clinical practice.

Cross-sectional studies have reported an association between major depressive episode (MDE) and obesity. The objective of this longitudinal analysis was to determine whether MDE increase the risk of becoming obese over a 10-year period.

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Data from the Canadian National Population Health Survey (NPHS) were used, a longitudinal study of a representative cohort of household residents in Canada. The incidence of obesity, defined as a body mass index (BMI) of 30, was evaluated in respondents who were 18 years or older at the time of a baseline interview in 1994. MDE was assessed using a brief diagnostic instrument.

At the end of the investigation, the risk of obesity was not elevated in association with MDE, either in unadjusted or covariate-adjusted analyses. The strongest predictor of obesity was a BMI in the overweight (but not obese) range. Effects were also seen for (younger) age, (female) sex, a sedentary activity pattern, low income and exposure to antidepressant medications. Unexpectedly, significant effects were seen for serotonin-reuptake-inhibiting antidepressants and venlafaxine, but neither for tricyclic antidepressants nor antipsychotic medications.

MDE does not appear to increase the risk of obesity. The cross-sectional associations that have been reported, albeit inconsistently, in the literature probably represent an effect of obesity on MDE risk. Pharmacologic treatment with antidepressants may be associated with an increased risk of obesity, and strategies to offset this risk may be useful in clinical practice.


Story Source:

The above story is based on materials provided by Journal Of Psychotherapy And Psychosomatics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Patten et al. Major Depression, Antidepressant Medication and the Risk of Obesity. Psychotherapy and Psychosomatics, 2009; 78 (3): 182 DOI: 10.1159/000209349

Cite This Page:

Journal Of Psychotherapy And Psychosomatics. "What Is The Risk Of Obesity While Taking Antidepressant Drugs?." ScienceDaily. ScienceDaily, 30 June 2009. <www.sciencedaily.com/releases/2009/06/090623090152.htm>.
Journal Of Psychotherapy And Psychosomatics. (2009, June 30). What Is The Risk Of Obesity While Taking Antidepressant Drugs?. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/06/090623090152.htm
Journal Of Psychotherapy And Psychosomatics. "What Is The Risk Of Obesity While Taking Antidepressant Drugs?." ScienceDaily. www.sciencedaily.com/releases/2009/06/090623090152.htm (accessed November 28, 2014).

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