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Carbon Monoxide, Although Toxic, Prevents Clotting In Mice

Date:
June 25, 2009
Source:
American Journal of Pathology
Summary:
Researchers have found that carbon monoxide (CO) can protect against arterial clotting in mice.
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Researchers led by Drs. James F. George and Anupam Agarwal at the University of Alabama at Birmingham have found that carbon monoxide (CO) can protect against arterial clotting in mice. 

Carbon monoxide poisoning is extremely toxic; exposure prevents oxygen delivery to body tissues and is often fatal. However, inflamed or injured tissues upregulate heme oxygenase-1 (HO-1), a protein that both protects cells and produces CO, suggesting that low levels of CO may have protective effects.

To determine if HO-1 and CO can protect against arterial clotting, Chen et al examined clotting mechanisms in mice that received arterial transplants. Absence of HO-1 in these mice resulted in significant mortality due to arterial clotting; however, treatment with a CO-releasing molecule both decreased clotting and improved survival.

Drs. George, Agarwal, and colleagues conclude that HO-1/CO plays an "important role …[in] protection against vascular arterial thrombosis in murine aortic allotransplantation.


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The above post is reprinted from materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chen B, Guo L, Fan C, Bolisetty S, Joseph R, Wright MM, Agarwal A, George JF. Carbon Monoxide Rescues Heme Oxygenase-1-deficient Mice from Arterial Thrombosis in Allogeneic Aortic Transplantation. Am J Pathol, 2009, 174: 2832-2839

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American Journal of Pathology. "Carbon Monoxide, Although Toxic, Prevents Clotting In Mice." ScienceDaily. ScienceDaily, 25 June 2009. <www.sciencedaily.com/releases/2009/06/090624211028.htm>.
American Journal of Pathology. (2009, June 25). Carbon Monoxide, Although Toxic, Prevents Clotting In Mice. ScienceDaily. Retrieved July 28, 2015 from www.sciencedaily.com/releases/2009/06/090624211028.htm
American Journal of Pathology. "Carbon Monoxide, Although Toxic, Prevents Clotting In Mice." ScienceDaily. www.sciencedaily.com/releases/2009/06/090624211028.htm (accessed July 28, 2015).

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