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Platypus Helps Illuminate Ovarian Cancer

Date:
June 27, 2009
Source:
University of Adelaide
Summary:
Researchers believe our oldest mammalian relative may help us to better understand ovarian cancer. DNA mapping of the platypus has uncovered an interesting relationship between their sex chromosomes and DNA sequences found in human ovarian cancer.

The platypus is helping Australian researchers to better understand ovarian cancer.
Credit: Photo by Nicole Duplaix

Researchers from the Royal Adelaide Hospital and University of Adelaide believe our oldest mammalian relative may help us to better understand ovarian cancer.

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University of Adelaide geneticist, Dr Frank Grutzner says DNA mapping of the platypus has uncovered an interesting relationship between their sex chromosomes and DNA sequences found in human ovarian cancer.

“We’ve identified DNA on the sex chromosomes of the platypus that is similar to the DNA that is affected in ovarian cancer and other diseases of reproduction like male infertility,” Dr Grutzner says.

“Cancers often show a large number of DNA changes and it is difficult to decide which ones are important for the development of the disease. The comparison with distantly related species like platypus helps us in identifying important DNA sequences that have been conserved by evolution over millions of years.

“We are excited by the fact that the analysis of the platypus genome gives us new directions in investigating the molecular basis of ovarian cancer.”

Working in partnership with Dr Grutzner is Assoc Prof Martin Oehler, Gynaecological Oncologist specialised in ovarian cancer treatment, from the Royal Adelaide Hospital who says it’s about finding new ways to tackle the disease.

“We hope this sort of research might one day lead to the development of an early detection test and more effective therapies against ovarian cancer,” Dr Oehler says.

“Ovarian cancer is the most lethal gynaecological cancer and ranks as the 6th most common cause of cancer death in Australian women.”

Both Dr Oehler and Dr Grutzner say the applications of this research are not limited to ovarian cancer, as they try to gain a better understanding of a number of diseases.


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Cite This Page:

University of Adelaide. "Platypus Helps Illuminate Ovarian Cancer." ScienceDaily. ScienceDaily, 27 June 2009. <www.sciencedaily.com/releases/2009/06/090626191301.htm>.
University of Adelaide. (2009, June 27). Platypus Helps Illuminate Ovarian Cancer. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2009/06/090626191301.htm
University of Adelaide. "Platypus Helps Illuminate Ovarian Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/06/090626191301.htm (accessed January 31, 2015).

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