Featured Research

from universities, journals, and other organizations

Risk Of Tuberculosis From Arthritis Medication Examined

Date:
July 3, 2009
Source:
Wiley-Blackwell
Summary:
Treatment with anti-tumor necrosis factor agents is recognized as a risk factor for tuberculosis in patients with immune-mediated inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriatic arthritis and psoriasis.

Treatment with anti-tumor necrosis factor (TNF) agents is recognized as a risk factor for tuberculosis (TB) in patients with immune-mediated inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriatic arthritis and psoriasis. Most TB cases develop as a result of reactivation of a latent TB infection, and health authorities worldwide recommend screening for latent TB and treating patients before initiating anti-TNF treatment.

Related Articles


A new study examined cases of TB associated with anti-TNF therapy and found that the risk of TB is higher for patients receiving anti-TNF monoclonal antibody therapy (infliximab or adalimumab) than for those receiving soluble TNF receptor therapy (etanercept).

Led by Xavier Mariette of the Universitι Paris-Sud, researchers set up a national registry in France to collect all cases of TB occurring during a three-year period in patients receiving anti-TNF therapy for any reason. Researchers collected data on 69 cases of TB, assessing risk factors for TB before anti-TNF therapy began and anti-TNF treatment history.

The results showed that the risk of TB for patients receiving anti-TNF therapy compared with the French population differed depending on the anti-TNF agent used; those receiving monoclonal anti-TNF therapy had a higher risk than those receiving sTNFR therapy. The risk of TB was higher during the first year of anti-TNF treatment, which favored the reactivation of latent TB. None of the patients who received correct prophylactic treatment for TB which is in France in most of the cases the association of INH and rifampicione for 3 months. Two thirds of TB cases occured in patients with negative skin tests.

The authors note that other countries have set up registries to investigate the safety of anti-TNF agents, but TB rates were so low that it was difficult to discern a difference in risk between the different types of anti-TNF agents; the current study, however, clearly demonstrates this difference. This study examined TB cases in the entire French population and researchers were therefore able to collect many more cases. In addition, it is the only registry to collect safety data for patients receiving anti-TNF therapy for any indication.

The mechanism by which TNF antagonists reactivate latent TB is not fully understood, but the authors suggest that differences in the action of the two types of anti-TNF agents in specific T helper cells (which play an important role in maximizing the capabilities of the immune system) and T regulatory cells (which suppress activation of the immune system) may help explain the differences in the risk of TB that were observed. The authors conclude that the differences seen with the two types of anti-TNF treatment may also explain the better efficacy of monoclonal antibody therapy in certain diseases, such as Crohn's disease, sarcoidosis and uveitis.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. F. Tubach, D. Salmon, P. Ravaud, Y. Allanore, P. Goupille, M. Brιban, B. Pallot-Prades, S. Pouplin, A. Sacchi, R.M. Chichemanian, S. Bretagne, D. Emilie, M. Lemann, O. Lorthololary, X. Mariette. Risk of Tuberculosis Higher with Monoclonal Antibody Therapy Than with Anti-Soluble Tumor Necrosis Factor Receptor Therapy. Arthritis & Rheumatism, July 2009

Cite This Page:

Wiley-Blackwell. "Risk Of Tuberculosis From Arthritis Medication Examined." ScienceDaily. ScienceDaily, 3 July 2009. <www.sciencedaily.com/releases/2009/06/090630163154.htm>.
Wiley-Blackwell. (2009, July 3). Risk Of Tuberculosis From Arthritis Medication Examined. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2009/06/090630163154.htm
Wiley-Blackwell. "Risk Of Tuberculosis From Arthritis Medication Examined." ScienceDaily. www.sciencedaily.com/releases/2009/06/090630163154.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) — Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) — Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) — As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) — A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins