Featured Research

from universities, journals, and other organizations

Cell Transplantation And Cardiac Repair

Date:
July 1, 2009
Source:
Cell Transplantation
Summary:
Two separate studies on cardiac repair by cell transplantation have found, respectively, that the best way to deliver autologous bone-marrow mononuclear cells to the heart following a myocardial infarction was via the anterograde intracoronary vein and that bone marrow cell transplants for limb ischemia induced angiogenesis in patients failing therapy and facing amputation. The first study found higher cell retention; the second demonstrated an alternative to amputation.

Two studies are highlighted in the current issue of Cell Transplantation. One of the studies is by a Brazil-based research team who looked at two different bone marrow cell delivery methods following myocardial infarction, and a second study from a team of researchers in Germany who used bone marrow stem cell transplants to repair limb ischemia with a goal of preventing amputations.

Related Articles


Two delivery techniques for stem cells

With evidence mounting that cell-based therapies can repair the injured myocardium following acute infarction, a Brazil-based research team addressed questions of the best way to safely deliver bone-marrow mononuclear cells (BMMNC) derived from the same patient (autologous cells) to the heart, following a heart attack caused by a prolonged interruption of blood flow leading to changes in the electrocardiogram (ST elevation myocardial infarction). They compared two different delivery techniques – through the anterograde intra-coronary (ICA) or via the retrograde intra-coronary artery vein (ICV). Researchers used radiolabeled cells to evaluate cell distribution patterns in the heart and their relationship with left ventricle function improvement.

"BMMNC retention by damaged heart tissue was apparently higher when the anterograde approach was used, although further studies are required to confirm this data," said corresponding author Dr. Hans Dohman of the Hospital Pro-Cardiaco in Rio de Janeiro, Brazil.

While previous reports observed that microvascular obstruction impairing cell uptake by the heart could be an issue, the team hypothesized that an intravenous approach may overcome that potential.

"We hypothesized that an intravenous approach might overcome this issue since the passage (diapedesis) of circulating cells into the adjacent cardiac tissue occurs on the venous side of microcirculation," added Dr. Dohman. "In addition, we found that the grade of obstruction of microcirculation does not correlate with the efficiency of cell delivery to the infarcted tissue."

The research team also found that higher cell retention correlated with better changes in observed ejection fraction from baseline to a six-month follow-up.

"Our data point toward a causal relationship between the total number of cells that participate in infarct repair and the final enhancement of cardiac function," concluded Dr. Dohman.

Bone marrow cell transplants for limb ischemia

Bone marrow cell transplantation has been shown to induce new blood vessel growth (angiogenesis) and foster improvements in patients with ischemic artery disease. This study, conducted by a Berlin-based group, evaluated the long-term effects of intermuscular, autologous bone marrow cell (aBMC) transplants in patients at major risk for amputation due to the loss of blood flow to a limb (limb ischemia) and who have failed or who are not candidates for surgical techniques to remove or bypass blockages. Patients who have failed surgical steps have high rates of amputation. In this study, 90 percent of patients participating in the study had been scheduled for major amputations; their long-term limb salvage rate was 53 percent.

"Our results suggest that aBMC transplants have the potential to treat severely ischemic limbs," said corresponding author Dr. Berthold Amann of the Franziskuskrankenhaus Berlin-Vascular Center. "Among the patients in whom limb salvage was successful and amputation avoided, the leg was also pain-free and usable."

Dr. Amann noted that the patients with limb salvage had better baseline perfusion than the eventually amputated patients. Among the limb-salvaged group, analgesic consumption was reduced by 62 percent and their total walking distance improved from zero to 40 meters.

"This study found that after aBMC, in addition to being spared amputation, a critically ischemic leg can have increased blood flow and support wound healing while patients have reduced pain," concluded Dr. Amann.

Researchers suggested that their results are yet to be confirmed, but a double-blind, placebo controlled study is currently underway.

"Should ours and other studies prove this therapy to be effective, adoption by hospitals other than large academic centers will require a simple method for processing the bone marrow," added Dr. Amann.

"The use of bone marrow derived cells for improvement in ischemic muscle in the heart or leg is very promising," said Amit N. Patel, associate professor of surgery at the University of Utah School of Medicine and the cardiovascular, skin, other tissue section editor of Cell Transplantation. "Both articles demonstrate that the route of delivery is one of the key determinants in having positive outcomes in the early clinical trials."

These two studies were published in Cell Transplantation (Vol. 18 No.3)


Story Source:

The above story is based on materials provided by Cell Transplantation. Note: Materials may be edited for content and length.


Cite This Page:

Cell Transplantation. "Cell Transplantation And Cardiac Repair." ScienceDaily. ScienceDaily, 1 July 2009. <www.sciencedaily.com/releases/2009/07/090701122714.htm>.
Cell Transplantation. (2009, July 1). Cell Transplantation And Cardiac Repair. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2009/07/090701122714.htm
Cell Transplantation. "Cell Transplantation And Cardiac Repair." ScienceDaily. www.sciencedaily.com/releases/2009/07/090701122714.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins