Featured Research

from universities, journals, and other organizations

Clocking Salt Levels In The Blood: Link Between The Circadian Rhythm And Salt Balance

Date:
July 5, 2009
Source:
Journal of Clinical Investigation
Summary:
New research suggests a link between the circadian rhythm and control of sodium (salt) levels in the blood of mice. Specifically, the circadian clock protein Period 1 was found to function downstream of the hormone aldosterone (a known controller of blood sodium levels and thereby blood pressure) to regulate levels of the alpha-subunit of the epithelial sodium channel in the mouse kidney.

New research, conducted by Charles Wingo and his colleagues, at the University of Florida, Gainsville, suggests a link between the circadian rhythm and control of sodium (salt) levels in mice.

Related Articles


The hormone aldosterone regulates levels of sodium in the blood and thereby helps control blood pressure. Although it is known that aldosterone regulates sodium levels by controlling expression of the alpha-subunit of the epithelial sodium channel (alpha-ENaC) in the kidney, the molecular pathway by which aldosterone modulates alpha-ENaC levels has not been determined. In a previous study to address this issue,

Wingo and colleagues found that aldosterone induced expression of the circadian clock gene Per1 in mouse cells, but the effects of this induction were not investigated. In this new study, they have revealed that the protein produced from the Per1 gene (Period 1) regulates expression of alpha-ENaC in the mouse kidney.

Importantly, in the absence of Period 1, expression of alpha-ENaC in the mouse kidney was decreased and sodium loss in the urine was increased. Since expression from the Per1 gene seemed to follow a circadian pattern, the authors suggest that the circadian clock has a role in balancing sodium levels in the body.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michelle L. Gumz et al. The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice. Journal of Clinical Investigation, DOI: 10.1172/JCI36908

Cite This Page:

Journal of Clinical Investigation. "Clocking Salt Levels In The Blood: Link Between The Circadian Rhythm And Salt Balance." ScienceDaily. ScienceDaily, 5 July 2009. <www.sciencedaily.com/releases/2009/07/090701182914.htm>.
Journal of Clinical Investigation. (2009, July 5). Clocking Salt Levels In The Blood: Link Between The Circadian Rhythm And Salt Balance. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2009/07/090701182914.htm
Journal of Clinical Investigation. "Clocking Salt Levels In The Blood: Link Between The Circadian Rhythm And Salt Balance." ScienceDaily. www.sciencedaily.com/releases/2009/07/090701182914.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins