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Developing A Safer Form Of Acetaminophen

Date:
July 16, 2009
Source:
American Chemical Society
Summary:
Scientists have developed a process for producing large batches of a new and potentially safer form of acetaminophen, the widely used pain-reliever now the source of growing concern over its potentially toxic effects on the liver.

Scientists in Louisiana are reporting development of a process for producing large batches of a new and potentially safer form of acetaminophen, the widely used pain-reliever now the source of growing concern over its potentially toxic effects on the liver. Their study could speed development of a next-generation pain-reliever.

In June, an advisory panel of the U. S. Food and Drug Administration recommended banning certain prescription pain relievers containing acetaminophen because of the drug's potential to cause liver damage when used in high doses. Mark Trudell and colleagues note in the study that scientists recently discovered a new form of acetaminophen that has similar potency to the original drug with a lower risk of liver toxicity. But until now, scientists have had difficulty producing this substance in quantities suitable for industrial scale-up.

The researchers describe a simple, efficient method for producing the new pain-reliever using only a few starting materials and a short series of chemical reactions. In laboratory studies, they used the new method to produce multigram quantities of the substance with 99 percent purity. The scientists point out that the new process can be performed on a much larger production level if needed.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Miao et al. First Multigram Preparation of SCP-123, A Novel Water-Soluble Analgesic. Organic Process Research & Development, 2009; 090625102714032 DOI: 10.1021/op900113b

Cite This Page:

American Chemical Society. "Developing A Safer Form Of Acetaminophen." ScienceDaily. ScienceDaily, 16 July 2009. <www.sciencedaily.com/releases/2009/07/090715101503.htm>.
American Chemical Society. (2009, July 16). Developing A Safer Form Of Acetaminophen. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2009/07/090715101503.htm
American Chemical Society. "Developing A Safer Form Of Acetaminophen." ScienceDaily. www.sciencedaily.com/releases/2009/07/090715101503.htm (accessed September 19, 2014).

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