Featured Research

from universities, journals, and other organizations

3-D Scaffold Of Living, Beating Heart Cells May Lead To Viable Strategies Of Transplanting Cells Into Diseased Hearts

Date:
July 23, 2009
Source:
University of Arizona Health Sciences Center
Summary:
Researchers have created a new 3-D scaffold of living, beating heart cells -- a promising step forward on the quest for viable strategies of transplanting cells into diseased hearts.

Research group leader Steven Goldman, MD, (right) and pre-doctoral Fellow Jordan Lancaster look at the microscopic image of a synthetic fiber mesh with beating heart muscle cells.
Credit: University of Arizona

It is an amazing sight: What looks like a tiny beating heart is actually a piece of synthetic, gauze-like mesh, barely the size of a fingernail, floating in a Petri dish. And yet it keeps squeezing away, nice and rhythmically.

Researchers at The University of Arizona's Sarver Heart Center and the Southern Arizona Veterans Administration Health Care System (SAVAHCS) have come a step closer to repairing hearts damaged by a heart attack or weakened by chronic heart failure.

"We have developed a delivery system that allows us to introduce living, healthy heart muscle cells into damaged areas of the heart in a way that is much more efficient than the conventionally practiced method of injecting cells into heart tissue," says study leader Steven Goldman, MD.

Unlike most existing approaches, in which cardiac cells with no supporting structure are injected into heart tissue, Goldman's group uses a patch (Theregen Inc. San Francisco) made from microscopically thin fibers that serve as a scaffold to which the cells can adhere.

The group's latest achievements have attracted the attention of the American Heart Association, who picked the research as one of the most noteworthy achievements of this year's Cardiovascular Sciences Annual Conference in Las Vegas, Nev.

"Ultimately, we hope to use our system in patients with chronic heart failure and, possibly, to prevent heart failure in patients who had a heart attack," says Jordan Lancaster, BS, a pre-doctoral fellow in Dr. Goldman's lab who will present the research at the meeting on July 21, 2009.

Dr. Goldman and his team discovered that when they "seed" a vicryl mesh patch with a sufficiently large number of heart muscle cells (2.5 million or more), the cells start behaving just like their counterparts in the real organ: They contract synchronously at about 70 beats per minute even without any outside stimulation.

"Our work shows that we can put living cells onto a biodegradable, 3-dimensional scaffold in a way that not only allows them to survive, but to spontaneously beat in a coordinated fashion," says Lancaster.

In addition to demonstrating the feasibility of using a synthetic mesh as a means to deliver living heart cells into a diseased heart, the group has already shown that the patch improves left ventricular function and blood flow when implanted into damaged heart muscle in a rat model of myocardial infarction.

Dr. Goldman believes that the construct developed in his lab provides a better vehicle to introduce cells into damaged heart muscle than conventional cell transplantation techniques, in which cells are injected directly into the heart.

"I think the main reason for the disappointing results people have seen with those clinical trials is that the cells end up in an environment that is not optimal for them to thrive in. Scar tissue offers poor blood supply and weak structural support for new cells to attach, survive and grow. Our patch offers just what cardiac muscle cells need: structural support, increased blood supply and chemicals secreted by the supporting cells on the patch that help the heart muscle cells grow and function."


Story Source:

The above story is based on materials provided by University of Arizona Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Arizona Health Sciences Center. "3-D Scaffold Of Living, Beating Heart Cells May Lead To Viable Strategies Of Transplanting Cells Into Diseased Hearts." ScienceDaily. ScienceDaily, 23 July 2009. <www.sciencedaily.com/releases/2009/07/090720191141.htm>.
University of Arizona Health Sciences Center. (2009, July 23). 3-D Scaffold Of Living, Beating Heart Cells May Lead To Viable Strategies Of Transplanting Cells Into Diseased Hearts. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2009/07/090720191141.htm
University of Arizona Health Sciences Center. "3-D Scaffold Of Living, Beating Heart Cells May Lead To Viable Strategies Of Transplanting Cells Into Diseased Hearts." ScienceDaily. www.sciencedaily.com/releases/2009/07/090720191141.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins