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Topical Treatment Improves Wound Healing

Date:
July 23, 2009
Source:
American Journal of Pathology
Summary:
Scientists have demonstrated that matrix metalloproteinases (MMPs) are instrumental in wound healing.

A group led by Dr. Yasunori Okada at Keio University in Tokyo, Japan has demonstrated that matrix metalloproteinases (MMPs) are instrumental in wound healing.

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Wound healing is the complex process of regenerating dermal and epidermal tissue after skin injury. MMPs, which can degrade proteins, are essential in breaking down wounded tissues to allow for wound healing; however, the specific function of individual MMPs in wounded tissues requires further study.

Using mouse models that lacked individual MMPs, Hattori et al noted that wound closure in MMP-deficient mice was significantly delayed compared with normal mice. Both MMPs examined played key roles in movement of skin cells, and one contributed to new blood vessel growth as well. Topical treatment with MMPs increased the rate of wound healing in these mice, providing a possible therapeutic strategy for treating delayed wound healing.

Dr. Okada and colleagues "have provided the first evidence of the importance of MMP-9 and MMP-13 on cutaneous wound healing by demonstrating that [mice that lack either] MMP-9, MMP-13, or both MMP-9/13 exhibit a significant delay in macroscopic wound closure and histological re-epithelialization. … [Their data] suggest the possible treatment of delayed wound healing by the application of the MMPs or inducers of the MMPs."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hattori et al. MMP-13 Plays a Role in Keratinocyte Migration, Angiogenesis, and Contraction in Mouse Skin Wound Healing. American Journal Of Pathology, 2009; DOI: 10.2353/ajpath.2009.081080

Cite This Page:

American Journal of Pathology. "Topical Treatment Improves Wound Healing." ScienceDaily. ScienceDaily, 23 July 2009. <www.sciencedaily.com/releases/2009/07/090723081523.htm>.
American Journal of Pathology. (2009, July 23). Topical Treatment Improves Wound Healing. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2009/07/090723081523.htm
American Journal of Pathology. "Topical Treatment Improves Wound Healing." ScienceDaily. www.sciencedaily.com/releases/2009/07/090723081523.htm (accessed March 27, 2015).

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