Featured Research

from universities, journals, and other organizations

Topical Treatment Improves Wound Healing

Date:
July 23, 2009
Source:
American Journal of Pathology
Summary:
Scientists have demonstrated that matrix metalloproteinases (MMPs) are instrumental in wound healing.

A group led by Dr. Yasunori Okada at Keio University in Tokyo, Japan has demonstrated that matrix metalloproteinases (MMPs) are instrumental in wound healing.

Wound healing is the complex process of regenerating dermal and epidermal tissue after skin injury. MMPs, which can degrade proteins, are essential in breaking down wounded tissues to allow for wound healing; however, the specific function of individual MMPs in wounded tissues requires further study.

Using mouse models that lacked individual MMPs, Hattori et al noted that wound closure in MMP-deficient mice was significantly delayed compared with normal mice. Both MMPs examined played key roles in movement of skin cells, and one contributed to new blood vessel growth as well. Topical treatment with MMPs increased the rate of wound healing in these mice, providing a possible therapeutic strategy for treating delayed wound healing.

Dr. Okada and colleagues "have provided the first evidence of the importance of MMP-9 and MMP-13 on cutaneous wound healing by demonstrating that [mice that lack either] MMP-9, MMP-13, or both MMP-9/13 exhibit a significant delay in macroscopic wound closure and histological re-epithelialization. … [Their data] suggest the possible treatment of delayed wound healing by the application of the MMPs or inducers of the MMPs."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hattori et al. MMP-13 Plays a Role in Keratinocyte Migration, Angiogenesis, and Contraction in Mouse Skin Wound Healing. American Journal Of Pathology, 2009; DOI: 10.2353/ajpath.2009.081080

Cite This Page:

American Journal of Pathology. "Topical Treatment Improves Wound Healing." ScienceDaily. ScienceDaily, 23 July 2009. <www.sciencedaily.com/releases/2009/07/090723081523.htm>.
American Journal of Pathology. (2009, July 23). Topical Treatment Improves Wound Healing. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2009/07/090723081523.htm
American Journal of Pathology. "Topical Treatment Improves Wound Healing." ScienceDaily. www.sciencedaily.com/releases/2009/07/090723081523.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins