Featured Research

from universities, journals, and other organizations

Twin Study Examines Associations Between Depression And Coronary Artery Disease

Date:
August 5, 2009
Source:
JAMA and Archives Journals
Summary:
Major depression and coronary artery disease are only modestly related throughout an individual's lifetime, but studying how the two interact over time and in twin pairs paints a more complex picture of the associations between the conditions, according to a new report. For example, the association between coronary artery disease onset and major depression risk is much stronger over time than vice versa.

Major depression and coronary artery disease are only modestly related throughout an individual's lifetime, but studying how the two interact over time and in twin pairs paints a more complex picture of the associations between the conditions, according to a new report. For example, the association between coronary artery disease onset and major depression risk is much stronger over time than vice versa.

"While an association between major depression and coronary artery disease has long been noted and recently confirmed, the direction and cause of this association remain unclear," the authors write as background information in the article. High cortisol levels, inflammation and changes in blood platelet function associated with depression may increase risk for coronary artery disease; coronary artery disease is a stressful event that may increase risk for depression; and shared genetic or environmental factors may underlie both conditions.

Kenneth S. Kendler, M.D., of Virginia Commonwealth University School of Medicine, Richmond, and colleagues studied 30,374 twins (average age 57) from the Swedish Twin Registry. Information was obtained from telephone interviews conducted between 1998 and 2003 and also from Swedish hospital discharge and death registers.

The results of statistical models over time and of twin pairs yielded several findings, the authors note. "First, the lifetime association between major depression and coronary artery disease in this sample was modest and did not differ substantially in men and women," they write. "Second, in more informative time-dependent analyses, coronary artery disease onset was associated with a nearly three-fold increased risk for depressive onset in that year and a nearly two-fold increase in subsequent years. The long-term effect of coronary artery disease on risk for major depression did not attenuate over time."

"Third, given an onset of major depression, the risk for coronary artery disease onset was increased 2.5-fold in that year and much more modestly in subsequent years," they continue. "The ongoing increased risk for coronary artery disease after major depression onset did not attenuate over time. Although modest, this future risk for coronary artery disease was strongly related to the severity and recurrence of major depression. Indeed, elevated future coronary artery disease risk was confined to individuals with recurrent episodes of major depression or those who meet more than the minimum number of diagnostic criteria."

In men, the increased risk for major depression was much greater in the year of coronary artery disease onset than in subsequent years. Women experienced a smaller spike in depression risk after diagnosis with coronary artery disease but had nearly the same risk thereafter. "When examined separately, in men, environmental effects, which are often acute, have a large role in major depression-coronary artery disease comorbidity, whereas in women, chronic effects, which are in part genetic, are more important," the authors conclude. "In men, genetic sources of major depression-coronary artery disease comorbidity are more important in younger members of the sample."

Supported in part by National Institute of Mental Health grants, a National Institute on Aging grant, the Swedish Scientific Council and the Swedish Department of Higher Education.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kendler et al. Major Depression and Coronary Artery Disease in the Swedish Twin Registry: Phenotypic, Genetic, and Environmental Sources of Comorbidity. Archives of General Psychiatry, 2009; 66 (8): 857 DOI: 10.1001/archgenpsychiatry.2009.94

Cite This Page:

JAMA and Archives Journals. "Twin Study Examines Associations Between Depression And Coronary Artery Disease." ScienceDaily. ScienceDaily, 5 August 2009. <www.sciencedaily.com/releases/2009/08/090803173121.htm>.
JAMA and Archives Journals. (2009, August 5). Twin Study Examines Associations Between Depression And Coronary Artery Disease. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2009/08/090803173121.htm
JAMA and Archives Journals. "Twin Study Examines Associations Between Depression And Coronary Artery Disease." ScienceDaily. www.sciencedaily.com/releases/2009/08/090803173121.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins