Featured Research

from universities, journals, and other organizations

Twin Study Examines Associations Between Depression And Coronary Artery Disease

Date:
August 5, 2009
Source:
JAMA and Archives Journals
Summary:
Major depression and coronary artery disease are only modestly related throughout an individual's lifetime, but studying how the two interact over time and in twin pairs paints a more complex picture of the associations between the conditions, according to a new report. For example, the association between coronary artery disease onset and major depression risk is much stronger over time than vice versa.

Major depression and coronary artery disease are only modestly related throughout an individual's lifetime, but studying how the two interact over time and in twin pairs paints a more complex picture of the associations between the conditions, according to a new report. For example, the association between coronary artery disease onset and major depression risk is much stronger over time than vice versa.

"While an association between major depression and coronary artery disease has long been noted and recently confirmed, the direction and cause of this association remain unclear," the authors write as background information in the article. High cortisol levels, inflammation and changes in blood platelet function associated with depression may increase risk for coronary artery disease; coronary artery disease is a stressful event that may increase risk for depression; and shared genetic or environmental factors may underlie both conditions.

Kenneth S. Kendler, M.D., of Virginia Commonwealth University School of Medicine, Richmond, and colleagues studied 30,374 twins (average age 57) from the Swedish Twin Registry. Information was obtained from telephone interviews conducted between 1998 and 2003 and also from Swedish hospital discharge and death registers.

The results of statistical models over time and of twin pairs yielded several findings, the authors note. "First, the lifetime association between major depression and coronary artery disease in this sample was modest and did not differ substantially in men and women," they write. "Second, in more informative time-dependent analyses, coronary artery disease onset was associated with a nearly three-fold increased risk for depressive onset in that year and a nearly two-fold increase in subsequent years. The long-term effect of coronary artery disease on risk for major depression did not attenuate over time."

"Third, given an onset of major depression, the risk for coronary artery disease onset was increased 2.5-fold in that year and much more modestly in subsequent years," they continue. "The ongoing increased risk for coronary artery disease after major depression onset did not attenuate over time. Although modest, this future risk for coronary artery disease was strongly related to the severity and recurrence of major depression. Indeed, elevated future coronary artery disease risk was confined to individuals with recurrent episodes of major depression or those who meet more than the minimum number of diagnostic criteria."

In men, the increased risk for major depression was much greater in the year of coronary artery disease onset than in subsequent years. Women experienced a smaller spike in depression risk after diagnosis with coronary artery disease but had nearly the same risk thereafter. "When examined separately, in men, environmental effects, which are often acute, have a large role in major depression-coronary artery disease comorbidity, whereas in women, chronic effects, which are in part genetic, are more important," the authors conclude. "In men, genetic sources of major depression-coronary artery disease comorbidity are more important in younger members of the sample."

Supported in part by National Institute of Mental Health grants, a National Institute on Aging grant, the Swedish Scientific Council and the Swedish Department of Higher Education.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kendler et al. Major Depression and Coronary Artery Disease in the Swedish Twin Registry: Phenotypic, Genetic, and Environmental Sources of Comorbidity. Archives of General Psychiatry, 2009; 66 (8): 857 DOI: 10.1001/archgenpsychiatry.2009.94

Cite This Page:

JAMA and Archives Journals. "Twin Study Examines Associations Between Depression And Coronary Artery Disease." ScienceDaily. ScienceDaily, 5 August 2009. <www.sciencedaily.com/releases/2009/08/090803173121.htm>.
JAMA and Archives Journals. (2009, August 5). Twin Study Examines Associations Between Depression And Coronary Artery Disease. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2009/08/090803173121.htm
JAMA and Archives Journals. "Twin Study Examines Associations Between Depression And Coronary Artery Disease." ScienceDaily. www.sciencedaily.com/releases/2009/08/090803173121.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins