Featured Research

from universities, journals, and other organizations

IgM In Urine Acts As Prognostic Indicator In Diabetes

Date:
August 6, 2009
Source:
BioMed Central
Summary:
A marker of the likely course of diabetic nephropathy has been found. An 18-year study has shown that Immunoglobulin M is a reliable predictor of cardiovascular complications in DN patients.

A marker of the likely course of diabetic nephropathy (DN) has been found. An 18-year study has shown that Immunoglobulin M (IgM) is a reliable predictor of cardiovascular complications in DN patients.

Omran Bakoush, MD, PhD, led a team of researchers from Lund University, Sweden, who carried out the research. He said, "To our knowledge, this study is the first to investigate the impact of increased urine IgM excretion on DN disease progression in type 1 diabetic patients. We found that those with increased urinary IgM excretion had a higher mortality from cardiovascular causes, and higher disease progression rate to end-stage renal disease. This association is largely independent of the level of albuminuria".

The researchers followed 139 patients with type 1 diabetes mellitus between 1984 and 2007. Patients with increased urine IgM excretion, measured by ELISA at the beginning of the study, were approximately three times more likely to die or progress to end-stage renal disease. Commenting on these findings, Dr Bakoush said, "These findings may offer a new approach to manage this rapidly increasing patient population. While measurement of albuminuria is routinely used to evaluate and manage patients with diabetes, increased urine IgM excretion would identify more specifically patients at risk for serious cardiovascular complications (death, and renal failure). If increased urine IgM excretion does reflects advanced atherosclerotic vascular disease, clinical trials would be justified to test whether modifying atherosclerotic factors, also decrease mortality and incidence of renal failure in diabetic patients with or without IgM-uria".


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rafid Tofik, Ole Torffvit, Bengt Rippe and Omran Bakoush. Increased urine IgM excretion predicts cardiovascular events in patients with type 1 diabetes nephropathy. BMC Medicine, (in press) [link]

Cite This Page:

BioMed Central. "IgM In Urine Acts As Prognostic Indicator In Diabetes." ScienceDaily. ScienceDaily, 6 August 2009. <www.sciencedaily.com/releases/2009/08/090803193647.htm>.
BioMed Central. (2009, August 6). IgM In Urine Acts As Prognostic Indicator In Diabetes. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/08/090803193647.htm
BioMed Central. "IgM In Urine Acts As Prognostic Indicator In Diabetes." ScienceDaily. www.sciencedaily.com/releases/2009/08/090803193647.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins