Featured Research

from universities, journals, and other organizations

Sex Hormones Associated With Broken Bones In Older Men

Date:
August 6, 2009
Source:
Endocrine Society
Summary:
Low levels of estradiol or high levels of sex hormone binding globulin (SHBG) are associated with an increased risk of osteoporotic fracture in older men, according to a new study. The study also finds that men with low levels of testosterone combined with high levels of SHBG are also at higher risk for bone fracture.

Low levels of estradiol or high levels of sex hormone binding globulin (SHBG) are associated with an increased risk of osteoporotic fracture in older men, according to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism. The study also finds that men with low levels of testosterone combined with high levels of SHBG are also at higher risk for bone fracture.

Testosterone is the predominant male sex hormone and estradiol is a sex hormone that provides most estrogen effects in both men and women. SHBG, a protein that binds to estradiol and testosterone in the blood, is known to reduce circulating sex steroid concentrations and has also been associated with fracture risk.

Previous studies have shown that with aging, sex hormone concentrations decline and fracture rates increase. Until now, few studies have adequately assessed the nature of the association of sex hormones with bone fracture risk or how measuring sex hormones might be useful in clinical practice.

This new study followed 1,436 men aged 65 years or older, for approximately five years. Researchers measured sex steroid levels using liquid chromatography/mass spectrometry, a highly accurate chemistry technique used for the specific detection and potential identification of chemicals in the presence of other chemicals in a complex mixture. The results of the study clearly demonstrate that estradiol and SHBG levels were most predictive of fracture risk, and men with the combination of low estradiol, low testosterone and high SHBG levels were at even higher risk for fracture—more than three times as high as men with average levels.

“In clinical practice today, estradiol and SHBG levels are not commonly measured when assessing skeletal health or fracture risk in men,” said Eric Orwoll, MD of Oregon Health and Science University and co-author of the study. “This practice should be revised. The results from our study strongly suggest that the measurement of both sex hormones, estradiol and testosterone, as well as SHBG levels in older men may help identify men at higher risk.”

Dr. Orwoll pointed out that many of the study participants were aged 80 years or older, a segment of the population that is expanding and is at higher fracture risk but has not been previously studied in this context.

Other researchers working on the study include Erin LeBlanc, Carrie Nielson, Lynn Marshall and Jodi Lapidus of Oregon Health and Science University in Portland; Elizabeth Barrett-Connor and Gail Laughlin of the University of California in San Diego; Kristine Ensrud of the University of Minnesota in Minneapolis; Andrew Hoffman of Stanford University in Palo Alto, Calif.; and Claes Ohlsson of the Shlgrenska Academy in Gφteborg, Sweden.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. The effects of serum testosterone, estradiol and sex hormone binding globulin levels on fracture risk in older men. Journal of Clinical Endocrinology & Metabolism, September 2009

Cite This Page:

Endocrine Society. "Sex Hormones Associated With Broken Bones In Older Men." ScienceDaily. ScienceDaily, 6 August 2009. <www.sciencedaily.com/releases/2009/08/090803222708.htm>.
Endocrine Society. (2009, August 6). Sex Hormones Associated With Broken Bones In Older Men. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2009/08/090803222708.htm
Endocrine Society. "Sex Hormones Associated With Broken Bones In Older Men." ScienceDaily. www.sciencedaily.com/releases/2009/08/090803222708.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) — A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) — The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) — A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins