Featured Research

from universities, journals, and other organizations

New Alzheimer's Gene Discovered

Date:
August 7, 2009
Source:
University of California - Irvine
Summary:
A new study has found that a gene called TOMM40 appears twice as often in people with Alzheimer's disease than in those without it. Alzheimer's, for which there is no cure, is the leading cause of elderly dementia.

A UC Irvine study has found that a gene called TOMM40 appears twice as often in people with Alzheimer's disease than in those without it. Alzheimer's, for which there is no cure, is the leading cause of elderly dementia.

Related Articles


Having the harmful form of TOMM40 significantly increases one's susceptibility when other risk factors – such as having a gene called ApoE-4 – are present, the new study reports. People who have ApoE-4 are three to eight times more likely to develop Alzheimer's.

"The TOMM40 gene influences the ease with which molecules can get in and out of mitochondria, the energy production center and stress mediator of cells. TOMM40 also processes materials that form amyloid plaque, a hallmark of Alzheimer's," said Dr. Steven Potkin, lead author of the study and UCI psychiatry & human behavior professor.

"With aging, the number and function of mitochondria decrease, accompanied by a parallel increased risk of developing Alzheimer's," he said. "This study points to the use of mitochondrial-based therapies for treating the disease."

The study will be published Aug. 7 in the journal PLoS One.

Supporting the UCI discovery is research presented recently at the International Conference on Alzheimer's Disease in Austria. Duke University scientists found that patients with TOMM40 developed Alzheimer's an average of seven years earlier than those without the gene.

In addition to Potkin, who is also the Robert R. Sprague Chair in Brain Imaging and director of UCI's Brain Imaging Center, UCI scientists Dr. Fabio Macciardi, Guia Guffanti, Dr. Anita Lakatos, Jessica Turner, Dr. Frithjof Kruggel and James Fallon worked on this study.

They collaborated with Andrew Saykin of Indiana University, Dr. Michael Weiner of UC San Francisco and Alzheimer's Disease Neuroimaging Initiative patients and investigators.

The study was funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute on Aging, the National Center for Research Resources and an anonymous foundation.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Irvine. "New Alzheimer's Gene Discovered." ScienceDaily. ScienceDaily, 7 August 2009. <www.sciencedaily.com/releases/2009/08/090806201916.htm>.
University of California - Irvine. (2009, August 7). New Alzheimer's Gene Discovered. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2009/08/090806201916.htm
University of California - Irvine. "New Alzheimer's Gene Discovered." ScienceDaily. www.sciencedaily.com/releases/2009/08/090806201916.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins