Featured Research

from universities, journals, and other organizations

New Alzheimer's Gene Discovered

Date:
August 7, 2009
Source:
University of California - Irvine
Summary:
A new study has found that a gene called TOMM40 appears twice as often in people with Alzheimer's disease than in those without it. Alzheimer's, for which there is no cure, is the leading cause of elderly dementia.

A UC Irvine study has found that a gene called TOMM40 appears twice as often in people with Alzheimer's disease than in those without it. Alzheimer's, for which there is no cure, is the leading cause of elderly dementia.

Related Articles


Having the harmful form of TOMM40 significantly increases one's susceptibility when other risk factors – such as having a gene called ApoE-4 – are present, the new study reports. People who have ApoE-4 are three to eight times more likely to develop Alzheimer's.

"The TOMM40 gene influences the ease with which molecules can get in and out of mitochondria, the energy production center and stress mediator of cells. TOMM40 also processes materials that form amyloid plaque, a hallmark of Alzheimer's," said Dr. Steven Potkin, lead author of the study and UCI psychiatry & human behavior professor.

"With aging, the number and function of mitochondria decrease, accompanied by a parallel increased risk of developing Alzheimer's," he said. "This study points to the use of mitochondrial-based therapies for treating the disease."

The study will be published Aug. 7 in the journal PLoS One.

Supporting the UCI discovery is research presented recently at the International Conference on Alzheimer's Disease in Austria. Duke University scientists found that patients with TOMM40 developed Alzheimer's an average of seven years earlier than those without the gene.

In addition to Potkin, who is also the Robert R. Sprague Chair in Brain Imaging and director of UCI's Brain Imaging Center, UCI scientists Dr. Fabio Macciardi, Guia Guffanti, Dr. Anita Lakatos, Jessica Turner, Dr. Frithjof Kruggel and James Fallon worked on this study.

They collaborated with Andrew Saykin of Indiana University, Dr. Michael Weiner of UC San Francisco and Alzheimer's Disease Neuroimaging Initiative patients and investigators.

The study was funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute on Aging, the National Center for Research Resources and an anonymous foundation.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Irvine. "New Alzheimer's Gene Discovered." ScienceDaily. ScienceDaily, 7 August 2009. <www.sciencedaily.com/releases/2009/08/090806201916.htm>.
University of California - Irvine. (2009, August 7). New Alzheimer's Gene Discovered. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2009/08/090806201916.htm
University of California - Irvine. "New Alzheimer's Gene Discovered." ScienceDaily. www.sciencedaily.com/releases/2009/08/090806201916.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins