Featured Research

from universities, journals, and other organizations

Better Test To Detect DNA For Diagnosing Disease, Investigating Crimes

Date:
September 3, 2009
Source:
American Chemical Society
Summary:
Researchers are reporting development of a new electronic sensor that shows promise as a faster, less expensive, and more practical alternative than tests now used to detect DNA. Such tests are done for criminal investigation, disease diagnosis, and other purposes. The new lab-on-a-chip test could lead to wider, more convenient use of DNA testing, the researchers say.

Scientists have developed a new electronic sensor that shows promise as a better way to detect DNA for diagnosing disease and investigating crimes.
Credit: Wikimedia Commons

Researchers in Singapore are reporting development of a new electronic sensor that shows promise as a faster, less expensive, and more practical alternative than tests now used to detect DNA. Such tests are done for criminal investigation, disease diagnosis, and other purposes. The new lab-on-a-chip test could lead to wider, more convenient use of DNA testing, the researchers say. Their study is scheduled for the Sept. 2 issue of the Journal of the American Chemical Society.

In the new study, Zhiqiang Gao and colleagues note that current methods for detecting DNA involve the used of the polymerase chain reaction (PCR). This technique "amplifies" or makes multiple copies of trace amounts of DNA, much as a photocopier produces multiple copies of documents, in order to detect the genetic material more easily. The amplification step is one reason why tests involving PCR can be too expensive, cumbersome, and imprecise for wider use.

The researchers describe development of a so-called "nanogap sensor" that appears to overcome those obstacles. The process uses a pair of micro-sized metal electrodes separated by a nanogap, 1/50,000 the width of a human hair, in combination with special chemical probes, to capture tiny segments of DNA. The newly formed "circuit" then translates the presence of DNA into an electrical signal so that it can be measured by a computer. In laboratory tests, the sensor showed "excellent" sensitivity at detecting trace amounts of human DNA and may eliminate the need for DNA amplification altogether, the researchers say.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Roy et al. Mass-Produced Nanogap Sensor Arrays for Ultrasensitive Detection of DNA. Journal of the American Chemical Society, 2009; 131 (34): 12211 DOI: 10.1021/ja901704t

Cite This Page:

American Chemical Society. "Better Test To Detect DNA For Diagnosing Disease, Investigating Crimes." ScienceDaily. ScienceDaily, 3 September 2009. <www.sciencedaily.com/releases/2009/08/090826110120.htm>.
American Chemical Society. (2009, September 3). Better Test To Detect DNA For Diagnosing Disease, Investigating Crimes. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2009/08/090826110120.htm
American Chemical Society. "Better Test To Detect DNA For Diagnosing Disease, Investigating Crimes." ScienceDaily. www.sciencedaily.com/releases/2009/08/090826110120.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins