Featured Research

from universities, journals, and other organizations

Gene Predicts Post-surgical Survival From Brain Metastasis Of Breast Cancer Patients

Date:
September 9, 2009
Source:
American Association for Cancer Research
Summary:
Researchers have identified a gene that may play a role in breast cancer metastasis to the brain.

Researchers at the National Cancer Institute have identified a gene that may play a role in breast cancer metastasis to the brain, according to a report in Molecular Cancer Research, a journal of the American Association for Cancer Research.

Diane Palmieri, Ph.D., a staff scientist at the NCI, said Hexokinase 2 overexpression was more highly expressed in brain metastasis in patients with breast cancer than in primary breast tumors.

"Importantly, this study was conducted in human tissue rather than animal models, so we are able to extrapolate data without the problems inherent in animal studies," said Palmieri.

Brunhilde Felding-Habermann, Ph.D., an associate professor at The Scripps Research Institute, said the findings are a major step forward in potential breast cancer treatments.

"Improvements in breast cancer therapy have made prognoses like brain metastasis a growing problem, and this research points to a potential target for future therapies," said Felding-Habermann.

Researchers performed analyses on both primary tumors and brain metastases. They found higher levels of Hexokinase 2 in brain metastases compared with unlinked primary tumors. Among resected brain metastases, these higher levels of Hexokinase 2 were linked with worse survival. The median survival for patients with high levels of Hexokinase 2 expression in their brain metastasis was 9.6 months compared with 17.5 months for those with lower expression.

Palmieri said that Hexokinase 2 plays a key role in glucose metabolism, which provides the energy tumors need to grow. It also impacts the cell survival process, apoptosis.

"Potential therapies would need to turn off this gene and thus starve the tumor of its growth potential," said Palmieri.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Gene Predicts Post-surgical Survival From Brain Metastasis Of Breast Cancer Patients." ScienceDaily. ScienceDaily, 9 September 2009. <www.sciencedaily.com/releases/2009/09/090901132804.htm>.
American Association for Cancer Research. (2009, September 9). Gene Predicts Post-surgical Survival From Brain Metastasis Of Breast Cancer Patients. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/09/090901132804.htm
American Association for Cancer Research. "Gene Predicts Post-surgical Survival From Brain Metastasis Of Breast Cancer Patients." ScienceDaily. www.sciencedaily.com/releases/2009/09/090901132804.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins