Featured Research

from universities, journals, and other organizations

Autoimmune Response Can Induce Pancreatic Tumor Rejection

Date:
September 9, 2009
Source:
American Association for Cancer Research
Summary:
Immune responses are capable of killing tumors before they can be directed toward normal body tissue, according to new scientific findings.

Immune responses are capable of killing tumors before they can be directed toward normal body tissue, according to new scientific findings published in Cancer Research, a journal of the American Association for Cancer Research.

"There are extremely precise mechanistic methods augmenting the ability of the immune system to distinguish between normal tissues and tumors," said lead researcher Richard G. Vile, Ph.D. "Understanding the multiple checks and safeguards against autoimmunity should allow us to understand more closely how to generate antitumor immunity."

Vile, professor of immunology in the Department of Molecular Medicine and the Department of Immunology at the Mayo Clinic, Rochester, Minn., and professor of biological therapy at the University of Leeds, United Kingdom, along with other colleagues, induced pathological damage to a normal organ, in this case the pancreas, with the immune adjuvant hsp70. They investigated whether that damage could lead to the development of T-cell responses against the normal pancreas.

Inflammatory killing of the normal pancreas induced a Th-1-like, anti-self response to pancreatic antigens. Rapid suppression and damage to the pancreas induced a very strong suppressive regulatory T-cell response — Treg. Even after Treg cells were depleted, Vile and colleagues found that Th-1-like response was insufficient to induce significant ongoing autoimmunity.

"We believe that although there are additional mechanisms that prevent autoimmunity, simply removing the Treg uncovered a good antitumor response," Vile said. "We were not expecting that it would be possible to cure tumors without autoimmunity. Our prediction was that we would have to generate potent autoimmunity and then the tumors would be rejected."

Based on this study, the researchers suggested that it is more difficult than presumed to induce autoimmunity against the pancreas because multiple immune safeguards exist to prevent potentially autoimmune T-cells from destroying the normal pancreas. Further, when comparing the immunoprotective mechanisms of different tissues, profound differences exist in response to pathogen-like damage.

Cancer Research editorial board member Ivan Borrello, M.D., believes this study highlights several unique aspects of tumor immunology. The immune response toward normal elements and tumors in different organs are mediated through different mechanisms and may require different approaches to achieve a beneficial therapeutic outcome, he said. Further, in certain situations like the pancreas, it may not be sufficient to prime effective anti-tumor immunity.

"This study demonstrates the increasing complexity within which both normal tissues and tumors can protect themselves against destruction and underscores the complex network regulating immune responsiveness," said Borrello, an associate professor in oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

These findings may lead to a new approach for the development of a cancer vaccination, Vile said, whereby scientists link the autoimmune and antitumor fields more closely than ever before.

Additional research is underway to evaluate this approach for the treatment of melanoma, as opposed to pancreatic cancer, and further studies are ongoing in prostate cancer. The field also needs to understand how to utilize and possibly sequence immune-mediated interventions in a more disease-focused and tailored manner, according to Borrello.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Autoimmune Response Can Induce Pancreatic Tumor Rejection." ScienceDaily. ScienceDaily, 9 September 2009. <www.sciencedaily.com/releases/2009/09/090908132231.htm>.
American Association for Cancer Research. (2009, September 9). Autoimmune Response Can Induce Pancreatic Tumor Rejection. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2009/09/090908132231.htm
American Association for Cancer Research. "Autoimmune Response Can Induce Pancreatic Tumor Rejection." ScienceDaily. www.sciencedaily.com/releases/2009/09/090908132231.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins