Featured Research

from universities, journals, and other organizations

Shining A Light On Disease: Tracking Light-emitting Bacteria During Infection

Date:
September 12, 2009
Source:
Society for General Microbiology
Summary:
By attaching light-emitting genes to infectious bacteria in an experimental system, researchers in Ireland have been able to track where in the body the bacteria go -- giving an insight into the path of the infection process leading to the development of more targeted treatments

By attaching light-emitting genes to infectious bacteria in an experimental system, researchers at University College, Cork, Ireland, have been able to track where in the body the bacteria go – giving an insight into the path of the infection process leading to the development of more targeted treatments.

At the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh, Dr Cormac Gahan described how his research team had manipulated the infectious food-borne pathogen Listeria monocytogenes to emit enough light for an ultra-sensitive camera system to detect these bacteria during infection of living mice in real time. This non-invasive procedure allowed individual animals to be analysed over the course of a lengthy infection and therefore reduced the numbers of animals required for infection studies.

This bioluminescence technology showed the researchers that Listeria bacteria migrated to the kidneys and gall bladders of normal mice during infection. In mice with cancer, the bacterium migrated very efficiently to the tumour tissue. The team went on to investigate the possibility that Listeria could be used to kill tumour cells by delivering DNA containing the codes for proteins to kill the tumour.

"Bioluminescence imaging in bacterial infections has great potential to provide information on the cause of infectious diseases," said Dr Gahan, "The technology allows the researcher to pinpoint exactly where in the body the bacteria reside during infection. We have also demonstrated that the technology can indicate which bacterial genes are switched on during infection. The use of this approach will underpin the development and testing of new vaccine and DNA-delivery vectors for protection against bacterial diseases."


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "Shining A Light On Disease: Tracking Light-emitting Bacteria During Infection." ScienceDaily. ScienceDaily, 12 September 2009. <www.sciencedaily.com/releases/2009/09/090908203427.htm>.
Society for General Microbiology. (2009, September 12). Shining A Light On Disease: Tracking Light-emitting Bacteria During Infection. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2009/09/090908203427.htm
Society for General Microbiology. "Shining A Light On Disease: Tracking Light-emitting Bacteria During Infection." ScienceDaily. www.sciencedaily.com/releases/2009/09/090908203427.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins