Featured Research

from universities, journals, and other organizations

Remodeling Tumor Vasculature: A New Approach To Therapy

Date:
September 16, 2009
Source:
Deutsche Gesellschaft fuer Immunologie e.V./German Society for Immunology
Summary:
Life-threatening tumors are fed by the uncontrolled growth of blood vessels within them that allows them to thrive – and to halt disease-fighting cells in their tracks. Reversing or re-arranging the growth of these vessels in combination with specific immune strategies is a promising new strategy for cancer therapy, according to researchers.

Life-threatening tumours are fed by the uncontrolled growth of blood vessels within them that allows them to thrive – and to halt disease-fighting cells in their tracks. Reversing or re-arranging the growth of these vessels in combination with specific immune strategies is a promising new strategy for cancer therapy, says Ruth Ganss, Professor at the Western Australian Institute for Medical Research, Perth, at the 2nd European Congress of Immunology ECI 2009 held in Berlin.

Currently, a lot of research effort goes into attempts to kill tumour vessels. Once tumour vessels are killed tumours grow slower. Ganss’ approach is novel in a way that she and her co-workers postulate that by remodelling tumour vessels as opposed of killing them, they make tumours more accessible for therapy. Their goal is to develop combination therapies where they activate immune cells and simultaneously change the tumour vessels to improve access by immune cells and ultimately tumour destruction.

“Our laboratory has identified several ways to interfere with growth of blood vessels in a tumour, a process called angiogenesis, and thus to improve therapy”, says Ganss.

For instance, the scientists have described a master gene that occurs in blood vessels within tumours. By removing this gene in mice, they have been able to reverse the process of angiogenesis so that tumour blood vessels appear more normal. “Importantly, this normalisation changes the tumour environment in a way that improves immune cell entry, meaning tumours can be destroyed”, Ganss stresses. In laboratory tests using mice, this resulted in dramatically improved survival rates.

The scientists also made use of the characteristics of the abnormal tumour vessels which provided them with a “homing address” to direct inflammatory factors into tumours. These factors then change the tumour vessels and activate them in a way that barriers are broken down and immune cells can enter the tumour and do a better job.


Story Source:

The above story is based on materials provided by Deutsche Gesellschaft fuer Immunologie e.V./German Society for Immunology. Note: Materials may be edited for content and length.


Cite This Page:

Deutsche Gesellschaft fuer Immunologie e.V./German Society for Immunology. "Remodeling Tumor Vasculature: A New Approach To Therapy." ScienceDaily. ScienceDaily, 16 September 2009. <www.sciencedaily.com/releases/2009/09/090915101641.htm>.
Deutsche Gesellschaft fuer Immunologie e.V./German Society for Immunology. (2009, September 16). Remodeling Tumor Vasculature: A New Approach To Therapy. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2009/09/090915101641.htm
Deutsche Gesellschaft fuer Immunologie e.V./German Society for Immunology. "Remodeling Tumor Vasculature: A New Approach To Therapy." ScienceDaily. www.sciencedaily.com/releases/2009/09/090915101641.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins