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Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma

Date:
September 16, 2009
Source:
World Journal of Gastroenterology
Summary:
A research team analyzed the differences and relevance of Yes-associated protein and survivin, and explored the correlation and significance of their expression in gastric carcinoma and precancerous lesions. It was found that YAP might play an important role as a carcinogenic factor and might induce survivin expression. Detecting both markers together might help in early diagnosis of gastric carcinoma.

Yes-associated protein (YAP) is a type of cellular adaptor protein and transcriptional co-activator. In recent years, some investigators have found YAP to be overexpressed and highly activated in hepatic cancers and mammary cancers, suggesting its tumorigenicity. Survivin is a new member of the inhibitor of apoptotic protein (IAP) family, which was initially cloned by the cDNA of the effector cell protease receptor-1 in the human genomic library in 1997.

A research team led by Professor Yan Xin, from The Fourth Laboratory of Cancer Institute in China measured the expression of YAP and survivin in normal gastric mucosa, precancerous lesions and gastric carcinoma using an immunohistochemical method to analyze the significance and correlations of the 2 factors with gastric carcinogenesis.

Their study is published on August 28, 2009 in the World Journal of Gastroenterology.

The investigation found that the expression of YAP and survivin in gastric carcinoma were positively correlated, and according to the data, they speculated that YAP might induce a high expression of cell proliferation-related factors and apoptotic inhibitors, such as Ki67, cIAP1 and survivin. Survivin might participate in gastric carcinogenesis, progression and metastasis by inhibiting apoptosis of gastric carcinoma cells and regulating cellular mitosis. Whether YAP and survivin collaborate to contribute to gastric carcinogenesis and progression requires further study.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Da et al. Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions. World Journal of Gastroenterology, 2009; 15 (32): 4055 DOI: 10.3748/wjg.15.4055

Cite This Page:

World Journal of Gastroenterology. "Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma." ScienceDaily. ScienceDaily, 16 September 2009. <www.sciencedaily.com/releases/2009/09/090916090909.htm>.
World Journal of Gastroenterology. (2009, September 16). Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2009/09/090916090909.htm
World Journal of Gastroenterology. "Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma." ScienceDaily. www.sciencedaily.com/releases/2009/09/090916090909.htm (accessed October 22, 2014).

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