Featured Research

from universities, journals, and other organizations

Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma

Date:
September 16, 2009
Source:
World Journal of Gastroenterology
Summary:
A research team analyzed the differences and relevance of Yes-associated protein and survivin, and explored the correlation and significance of their expression in gastric carcinoma and precancerous lesions. It was found that YAP might play an important role as a carcinogenic factor and might induce survivin expression. Detecting both markers together might help in early diagnosis of gastric carcinoma.

Yes-associated protein (YAP) is a type of cellular adaptor protein and transcriptional co-activator. In recent years, some investigators have found YAP to be overexpressed and highly activated in hepatic cancers and mammary cancers, suggesting its tumorigenicity. Survivin is a new member of the inhibitor of apoptotic protein (IAP) family, which was initially cloned by the cDNA of the effector cell protease receptor-1 in the human genomic library in 1997.

A research team led by Professor Yan Xin, from The Fourth Laboratory of Cancer Institute in China measured the expression of YAP and survivin in normal gastric mucosa, precancerous lesions and gastric carcinoma using an immunohistochemical method to analyze the significance and correlations of the 2 factors with gastric carcinogenesis.

Their study is published on August 28, 2009 in the World Journal of Gastroenterology.

The investigation found that the expression of YAP and survivin in gastric carcinoma were positively correlated, and according to the data, they speculated that YAP might induce a high expression of cell proliferation-related factors and apoptotic inhibitors, such as Ki67, cIAP1 and survivin. Survivin might participate in gastric carcinogenesis, progression and metastasis by inhibiting apoptosis of gastric carcinoma cells and regulating cellular mitosis. Whether YAP and survivin collaborate to contribute to gastric carcinogenesis and progression requires further study.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Da et al. Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions. World Journal of Gastroenterology, 2009; 15 (32): 4055 DOI: 10.3748/wjg.15.4055

Cite This Page:

World Journal of Gastroenterology. "Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma." ScienceDaily. ScienceDaily, 16 September 2009. <www.sciencedaily.com/releases/2009/09/090916090909.htm>.
World Journal of Gastroenterology. (2009, September 16). Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2009/09/090916090909.htm
World Journal of Gastroenterology. "Yes-associated Protein: Early Diagnosis Of Gastric Carcinoma." ScienceDaily. www.sciencedaily.com/releases/2009/09/090916090909.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins