Featured Research

from universities, journals, and other organizations

Anticancer Nanotech: Protein Can Be Used To Carry Radioactive Isotopes To Cancerous Tumor

Date:
September 21, 2009
Source:
Inderscience
Summary:
Tiny particles of albumin, a protein found in the blood, can be used to carry radioactive isotopes to the site of a cancerous tumor in the body and so avoid many of the side-effects of conventional radiotherapy, according to a new study.

Tiny particles of albumin, a protein found in the blood, can be used to carry radioactive isotopes to the site of a cancerous tumour in the body and so avoid many of the side-effects of conventional radiotherapy.

Related Articles


Virginia Nazarica Borza, Elena Neacsu and Catalina Mihaela Barna of the "Horia Hulubei" National Institute of R&D for Physics and Nuclear Engineering, in Bucharest, Romania, report details of the preparation of human serum albumin nanospheres labelled with rhenium-188 radioisotope, in the current issue of the International Journal of Nanotechnology and Biomaterials.

Drug-delivery agents that can target the site of disease in the body have often been referred to "magic bullets". Previously, such systems have not lived up to their name. However, the advent of nanotechnology is bringing such agents a step closer. The delivery of drug directly to the site where it is needed and at the level that is required for treatment is essential if efficacy is to be improved and side effects minimised. Due to their particular chemical and physical properties, nanoparticles offer the possibility of devloping such therapeutic or diagnostic agents.

Now, Borza and colleagues have found a way to load up nanospheres of water-soluble protein from blood plasma with the radioactive element rhenium-188. This radionuclide emits beta particles, high-energy electrons, as it decays radioactively, but is short-lived so causes no long-term problems. Such high-energy beta-emitter radioisotopes coupled to nanoparticles could deliver a high therapeutic dose of radioactivity to a tumour, while sparing more distant tissues from toxicity.

The team has determined the optimal safe parameters for making the cancer-killing nanospheres and tested their overall stability in the laboratory. They load up the albumin nanoparticles, a process known as radiolabelling, by heating the albumin nanospheres and rhenium-188, in the presence of a tin salt, stannous chloride and a claw-like chelating agent, tartrate, which can grab on to the rhenium-188.

The next step is to carry out pre-clinical studies on how well the radiolabelled nanospheres can target tumour cells and to demonstrate by how much therapeutic efficacy might be improved using these drug-delivery agents.


Story Source:

The above story is based on materials provided by Inderscience. Note: Materials may be edited for content and length.


Cite This Page:

Inderscience. "Anticancer Nanotech: Protein Can Be Used To Carry Radioactive Isotopes To Cancerous Tumor." ScienceDaily. ScienceDaily, 21 September 2009. <www.sciencedaily.com/releases/2009/09/090916092651.htm>.
Inderscience. (2009, September 21). Anticancer Nanotech: Protein Can Be Used To Carry Radioactive Isotopes To Cancerous Tumor. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2009/09/090916092651.htm
Inderscience. "Anticancer Nanotech: Protein Can Be Used To Carry Radioactive Isotopes To Cancerous Tumor." ScienceDaily. www.sciencedaily.com/releases/2009/09/090916092651.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins