Featured Research

from universities, journals, and other organizations

Safe Dosages Of Common Pain Reliever May Help Prevent Conditions Related To Aging, Research Shows

Date:
September 24, 2009
Source:
Marshall University
Summary:
Recent studies have shown that use of the common pain reliever acetaminophen may help prevent age-associated muscle loss and other conditions. Their study examined how acetaminophen may affect the regulation of protein kinase B (Akt), an enzyme known to play an important role in regulation of cellular survival, proliferation and metabolism.

Recent studies conducted by Dr. Eric Blough and his colleagues at Marshall University have shown that use of the common pain reliever acetaminophen may help prevent age-associated muscle loss and other conditions.

Their study examined how acetaminophen may affect the regulation of protein kinase B (Akt), an enzyme known to play an important role in regulation of cellular survival, proliferation and metabolism.

The researchers’ data indicates that aging skeletal muscles experience a decrease in the proper functioning of the enzyme and that acetaminophen intervention in aged animals could be used to restore Akt activity to a level comparable to that seen in young animals. In turn, this improvement in Akt activity was associated with improvements in muscle cell size and decreased muscle cell death.

“Using a model that closely mimics many of the age-associated physiological changes observed in humans, we were able to demonstrate that chronic acetaminophen treatment in a recommended dosage is not only safe but might be beneficial for the treatment of the muscle dysfunction many people experience as they get older,” said Blough, an associate professor in the university’s Department of Biological Sciences.

The lab’s work, which was published in the July 29 issue of the research journal PLoS ONE, is the first study to show that acetaminophen ingestion, at least in animals, can be safely used for the treatment of age-related muscle loss. This finding could have far-reaching implications, given the fact that people age 65 and older make up the fastest-growing segment of the U.S. population.

Additional research in their laboratory, which was published in the March issue of the journal Diabetes/Metabolism Research and Reviews, demonstrates the medication may also be useful in diminishing the severity of age-associated hyperglycemia, commonly referred to as high blood sugar.

“It is thought that acetaminophen may exert its action by decreasing the amount of reactive oxygen species,” explained Dr. Miaozong Wu, the lead author and a postdoctoral fellow in Blough’s lab. “Given the finding that increases in reactive oxygen species may play a role in the development of several age-associated disorders, it is possible that acetaminophen could be used to treat many different types of conditions.”

Dr. John Maher, vice president for research and executive director of the Marshall University Research Corporation, said, “These findings are yet another indication that Marshall’s researchers are conducting vital research in areas of great importance to human health and safety. I could not be more pleased and wish Dr. Blough and his team continued success.”

The research was supported with funding from McNeil Pharmaceutical.

According to Blough, scientists in his lab will now turn their attention to examining other physiological systems, such as the heart and blood vessels, to see if acetaminophen therapy might have similar benefits for people with cardiovascular disease.


Story Source:

The above story is based on materials provided by Marshall University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Miaozong Wu, Anjaiah Katta, Murali K. Gadde, Hua Liu, Sunil K. Kakarla, Jacqueline Fannin, Satyanarayana Paturi, Ravi K. Arvapalli, Kevin M. Rice, Yeling Wang, Eric R. Blough. Aging-Associated Dysfunction of Akt/Protein Kinase B: S-Nitrosylation and Acetaminophen Intervention. PLoS ONE, 2009; 4(7): e6430 DOI: 10.1371/journal.pone.0006430

Cite This Page:

Marshall University. "Safe Dosages Of Common Pain Reliever May Help Prevent Conditions Related To Aging, Research Shows." ScienceDaily. ScienceDaily, 24 September 2009. <www.sciencedaily.com/releases/2009/09/090923163849.htm>.
Marshall University. (2009, September 24). Safe Dosages Of Common Pain Reliever May Help Prevent Conditions Related To Aging, Research Shows. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/09/090923163849.htm
Marshall University. "Safe Dosages Of Common Pain Reliever May Help Prevent Conditions Related To Aging, Research Shows." ScienceDaily. www.sciencedaily.com/releases/2009/09/090923163849.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins