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Childhood Kidney Disorder Has Lasting Effects

Date:
September 28, 2009
Source:
American Society of Nephrology
Summary:
A kidney condition that can arise in children and was until recently believed to disappear after puberty may persist into adulthood and cause significant long-term complications, according to a new study. The findings indicate that better treatment options are needed for children with the disorder, called minimal change nephrotic syndrome.

A kidney condition that can arise in children and was until recently believed to disappear after puberty may persist into adulthood and cause significant long-term complications, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that better treatment options are needed for children with the disorder, called minimal change nephrotic syndrome.

Many children who develop minimal change nephrotic syndrome—a disorder that largely affects the blood filtering structures of the kidneys—can be successfully treated with prednisone. The cause of the syndrome is unknown but may be related to an autoimmune illness. Unfortunately, 10% to 40% of patients suffer relapses after childhood and must be treated long-term with immunosuppressive drugs.

To determine the lasting health effects of minimal change nephrotic syndrome and its treatment in patients who are not cured during childhood, Henriette Kyrieleis, MD, PhD (Radboud University Nijmegen Medical Centre, The Netherlands) and Elena Levtchenko, MD, PhD (University Hospitals Leuven, Belgium), and their colleagues studied 15 adult patients with the disease. The investigators ran a number of tests on the patients—including blood and urine analyses; semen analyses in men; x-ray exams; eye exams; and genetic tests.

Hypertension was found in 7 of the 15 patients, and osteoporosis was present in five of the patients. Eye exams revealed nearsightedness in 10 of the patients and cataracts in three of the patients. In the eight male participants in the study, low sperm count was found in one patient, reduced sperm motility was detected in four patients, and defective sperm were present in six patients.

The analysis revealed that while adults being treated for minimal change nephrotic syndrome may maintain normal kidney function, they frequently experience other serious health problems. Long-term immunosuppressive treatments may be the cause and/or may contribute to the development of these adverse effects. "Our study underscores a need for more effective and less toxic therapies for relapsing minimal change nephrotic syndrome," the authors wrote.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Henriette A.C. Kyrieleis, Marije M. Lowik, Ilse Pronk, Hans R. M. Cruysberg, Jan A.M. Kremer, Wim J.G. Oyen, Bert L.P. van den Heuvel, Jack F.M. Wetzels, Elena N. Levtchenko. Long-Term Outcome of Biopsy-Proven, Frequently Relapsing Minimal-Change Nephrotic Syndrome in Children. Clinical Journal of the American Society Nephrology, 2009; DOI: 10.2215/CJN.05691108

Cite This Page:

American Society of Nephrology. "Childhood Kidney Disorder Has Lasting Effects." ScienceDaily. ScienceDaily, 28 September 2009. <www.sciencedaily.com/releases/2009/09/090924185531.htm>.
American Society of Nephrology. (2009, September 28). Childhood Kidney Disorder Has Lasting Effects. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2009/09/090924185531.htm
American Society of Nephrology. "Childhood Kidney Disorder Has Lasting Effects." ScienceDaily. www.sciencedaily.com/releases/2009/09/090924185531.htm (accessed April 20, 2014).

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